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Ⅰ型干扰素：是敌是友？

Type I interferon: friend or foe?

机构信息

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

出版信息

J Exp Med. 2010 Sep 27;207(10):2053-63. doi: 10.1084/jem.20101664. Epub 2010 Sep 13.

DOI:10.1084/jem.20101664
PMID:20837696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2947062/
Abstract

Although the role of type I interferon (IFN) in the protection against viral infections has been known and studied for decades, its role in other immunologically relevant scenarios, including bacterial infections, shock, autoimmunity, and cancer, is less well defined and potentially much more complicated.

摘要

尽管人们已经了解并研究了 I 型干扰素（IFN）在抗病毒感染中的作用已有数十年，但它在其他免疫相关情况下（包括细菌感染、休克、自身免疫和癌症）的作用尚未得到明确界定，而且可能更加复杂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/834f/2947062/53fa66ff1d2f/JEM_20101664_RGB_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/834f/2947062/c0d2deeffafd/JEM_20101664_RGB_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/834f/2947062/03c57119a377/JEM_20101664_RGB_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/834f/2947062/53fa66ff1d2f/JEM_20101664_RGB_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/834f/2947062/c0d2deeffafd/JEM_20101664_RGB_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/834f/2947062/03c57119a377/JEM_20101664_RGB_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/834f/2947062/53fa66ff1d2f/JEM_20101664_RGB_Fig3.jpg

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本文引用的文献

1
Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267.支柱文章：病毒干扰。I. 干扰素。《伦敦皇家学会学报B辑：生物科学》。1957年。第147卷：第258 - 267页。
J Immunol. 2015 Sep 1;195(5):1911-20.
2
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.人结核分枝杆菌感染中干扰素诱导的中性粒细胞驱动的血液转录特征。
Nature. 2010 Aug 19;466(7309):973-7. doi: 10.1038/nature09247.
3
Antiproliferative Properties of Type I and Type II Interferon.I型和II型干扰素的抗增殖特性。
REGγ通过降解PPP2CB激活TBK1-IFNβ信号通路来调节抗病毒反应。
Cell Mol Life Sci. 2025 Jul 30;82(1):296. doi: 10.1007/s00018-025-05816-4.
4
The Role of Type I Interferons in Tuberculosis and in Tuberculosis-Risk-Associated Comorbidities.I型干扰素在结核病及结核病相关合并症中的作用
Infect Dis Rep. 2025 Jul 8;17(4):81. doi: 10.3390/idr17040081.
5
Polio virotherapy provokes MDA5 signaling and CD4 T cell help to mediate cancer vaccination.脊髓灰质炎病毒疗法激发黑色素瘤分化相关基因5信号传导和CD4 T细胞辅助作用以介导癌症疫苗接种。
Microbiol Mol Biol Rev. 2025 Jul 8:e0004024. doi: 10.1128/mmbr.00040-24.
6
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Front Cell Infect Microbiol. 2025 Jun 17;15:1613922. doi: 10.3389/fcimb.2025.1613922. eCollection 2025.
7
Interferons in human inborn errors of disease.人类先天性疾病中的干扰素。
mBio. 2025 Aug 13;16(8):e0157025. doi: 10.1128/mbio.01570-25. Epub 2025 Jun 24.
8
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9
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Front Microbiol. 2025 May 9;16:1567288. doi: 10.3389/fmicb.2025.1567288. eCollection 2025.
10
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Pharmaceuticals (Basel). 2010 Mar 30;3(4):994-1015. doi: 10.3390/ph3040994.
4
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5
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6
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J Clin Invest. 2010 May;120(5):1674-82. doi: 10.1172/JCI40817. Epub 2010 Apr 12.