Diao Ran, Xu Feng, Wang Xuan-ding
Department of Respiratory Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 Jul;41(4):464-8. doi: 10.3785/j.issn.1008-9292.2012.04.018.
Interferons (IFNs) are cytokines playing an important role in immune responses. Interferons are classified into two distinct types according to specific interferon receptors(IFNR). Type I IFNs include IFN-α and IFN-β, whereas IFN-γ is type II IFN. It is well known that type I IFNs have important roles in the host defense against viruses through activation of interferon receptor A (IFNAR). However, many recent studies have also demonstrated that type I IFNs have effects on immune responses to bacterial infection. This review focuses on the immune regulation of type I IFN-mediated signal pathways in bacterial infections such as Listeria monocytogenes, Streptococcus, Mycobacterium tuberculosis, Bacillus anthracis, Legionella, Pseudomonas aeruginosa and others.
干扰素（IFNs）是在免疫反应中发挥重要作用的细胞因子。根据特异性干扰素受体（IFNR），干扰素可分为两种不同类型。I型干扰素包括IFN-α和IFN-β，而IFN-γ是II型干扰素。众所周知，I型干扰素通过激活干扰素受体A（IFNAR）在宿主抵御病毒方面发挥重要作用。然而，最近许多研究也表明，I型干扰素对细菌感染的免疫反应有影响。本综述重点关注I型干扰素介导的信号通路在细菌感染（如单核细胞增生李斯特菌、链球菌、结核分枝杆菌、炭疽芽孢杆菌、军团菌、铜绿假单胞菌等）中的免疫调节作用。
