Department of Pharmacology, Kawasaki Medical School, Japan.
J Pharmacol Sci. 2010;114(2):234-7. doi: 10.1254/jphs.10146sc. Epub 2010 Sep 11.
In the present study, we investigated whether ethanol physical dependence causes changes of serotonin transporter (SERT) expression in the brain. SERT expression increased in the cingulate cortex, nucleus accumbens, hippocampal CA1-CA3 layers, and mediodorsal nucleus of the thalamus and decreased in the basolateral nucleus of the amygdala. In addition, chronic ethanol treatment increased SERT mRNA in the dorsal raphe nucleus from which serotonergic neurons originate, although no SERT mRNA was detected in the regions where SERT protein increased. These findings suggest that alteration of SERT levels in the brain may be related to emotional changes observed in ethanol physical dependence.
在本研究中，我们调查了乙醇躯体依赖是否会引起大脑中 5-羟色胺转运体（SERT）表达的变化。SERT 的表达在扣带回皮质、伏隔核、海马 CA1-CA3 层和丘脑背内侧核中增加，而在杏仁核基底外侧核中减少。此外，慢性乙醇处理增加了源自 5-羟色胺能神经元的中缝背核中的 SERTmRNA，尽管在 SERT 蛋白增加的区域没有检测到 SERTmRNA。这些发现表明，大脑中 SERT 水平的改变可能与乙醇躯体依赖中观察到的情绪变化有关。
