RP-2, Health Physics Measurements, Radiation Protection, Mailstop G761, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Health Phys. 2010 Oct;99(4):532-8. doi: 10.1097/HP.0b013e3181d18c61.
Chelation treatments with dosages of 1 g of either Ca-DTPA (Trisodium calcium diethylenetriaminepentaacetate) or Zn-DTPA (Trisodium zinc diethylenetriaminepentaacetate) were undertaken at Los Alamos Occupational Medicine in three recent cases of wounds contaminated with metallic forms of Pu. All cases were finger punctures, and each chelation injection contained the same dosage of DTPA. One subject was treated only once, while the other two received multiple injections. Additional measurements of wound, urine, and excised tissues were taken for one of the cases. These additional measurements served to improve the estimate of the efficacy of the chelation treatment. The efficacy of the chelation treatments was compared for the three cases. Results were interpreted using models, and useful heuristics for estimating the intake amount and final committed doses were presented. In spite of significant differences in the treatments and in the estimated intake amounts and doses amongst the three cases, a difference of four orders of magnitude was observed between the highest excretion data point and the values observed at about 100 d for all cases. Differences between efficacies of Zn-DTPA and Ca-DTPA could not be observed in this study. An efficacy factor of about 50 was observed for a chelation treatment, which was administered at about 1.5 y after the incident, though the corresponding averted dose was very small (LA-UR 09-02934).
在 Los Alamos 职业医学中心，对最近三例被金属形式的 Pu 污染的伤口进行了 1 g 剂量的 Ca-DTPA（三钠钙二乙三胺五乙酸）或 Zn-DTPA（三钠锌二乙三胺五乙酸）螯合治疗。所有病例均为手指刺伤，每个螯合注射均含有相同剂量的 DTPA。一名受试者仅接受了一次治疗，而另外两名受试者接受了多次注射。对其中一例进行了额外的伤口、尿液和切除组织测量。这些额外的测量有助于提高螯合治疗效果的估计。对三个病例的螯合治疗效果进行了比较。使用模型对结果进行了解释，并提出了有用的启发式方法来估计摄入量和最终的承诺剂量。尽管三个病例的治疗方法、估计摄入量和剂量存在显著差异，但在所有病例中，最高排泄数据点与约 100 天时观察到的值之间存在四个数量级的差异。在这项研究中，没有观察到 Zn-DTPA 和 Ca-DTPA 的疗效差异。在事故发生约 1.5 年后进行的螯合治疗观察到约 50 的疗效因子，尽管对应的避免剂量非常小（LA-UR 09-02934）。
