Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Health Phys. 2010 Oct;99(4):483-94. doi: 10.1097/HP.0b013e3181d96381.
A 1985 plutonium puncture wound resulted in the initial deposition of 48 kBq of transuranic alpha activity, primarily 239+240Pu and 241Am, in a worker's right index finger. Surgical excisions in the week following reduced the long-term residual wound activity to 5.4 kBq, and 164 DTPA chelation therapy administrations over 17 mo resulted in urinary excretion of about 7 kBq. The case was published in 1988, but now 24 y of follow-up data are available. Annual bioassays have included in-vivo measurements of 241Am in the wound, skeleton, liver, lung, and axillary lymph nodes, and urinalyses for plutonium and 241Am. These measurements have shown relatively stable levels of 241Am at the wound site, with gradually increasing amounts of 241Am detected in the skeleton. Liver measurements have shown erratic detection of 241Am, and the lung measurements indicate Am but as interference from activity in the axillary lymph nodes and skeleton rather than activity in the lung. Urine excretion of Pu since termination of chelation therapy has typically ranged from 10 to 20 mBq d, with Am excretion about 10% of that for 239+240Pu. Annual routine medical exams have not identified any adverse health effects associated with the intake.
1985 年，一名工人的右食指被钚弹刺伤，导致最初沉积了 48kBq 的超铀放射性 α 活度，主要是 239+240Pu 和 241Am。在刺伤后的一周内进行了外科切除，将长期残留的伤口活度降低到 5.4kBq，在 17 个月内进行了 164 次 DTPA 螯合治疗，导致尿液中排出约 7kBq。该病例于 1988 年发表，但现在已经有 24 年的随访数据。年度生物监测包括对伤口、骨骼、肝脏、肺和腋窝淋巴结中的 241Am 进行体内测量，以及对尿液中的钚和 241Am 进行分析。这些测量结果表明，伤口处的 241Am 水平相对稳定，骨骼中逐渐检测到更多的 241Am。肝脏测量结果显示 241Am 的检测结果不稳定，而肺部测量结果表明存在 Am，但这是由于腋窝淋巴结和骨骼中的活性干扰，而不是肺部中的活性。螯合治疗结束后，尿液中排出的 Pu 量通常在 10 到 20mBq/d 之间，而 Am 的排出量约为 239+240Pu 的 10%。年度常规体检未发现与摄入相关的任何不良健康影响。
