视交叉上核生物钟中血管活性肠肽释放的调节
Regulation of vasoactive intestinal polypeptide release in the suprachiasmatic nucleus circadian clock.
作者信息
Francl Jessica M, Kaur Gagandeep, Glass John David
机构信息
Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA.
出版信息
Neuroreport. 2010 Nov 17;21(16):1055-9. doi: 10.1097/WNR.0b013e32833fcba4.
Abstract
Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, however, as in-vivo SCN VIP release has never been measured. Here, SCN microdialysis was used to investigate mechanisms regulating VIP. Hamsters under light-dark cycle of 14:10 exhibited a daily peak in synaptic VIP release near midday. Under constant darkness, this output was arrhythmic. Light and the glutamatergic agonist, N-methyl-D-aspartate, stimulated VIP release at night, whereas the serotonin (1A,7) agonist, (±)8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, suppressed release at midday. Hence, SCN VIP activity is stimulated by photic input and inhibited by serotonin.
摘要
视交叉上核（SCN）的哺乳动物生物钟节律受来自视网膜的光信号输入调节。视网膜接收单元部分地通过释放血管活性肠肽（VIP）来调节SCN起搏细胞的节律性。然而，这一过程的潜在本质仍是推测性的，因为尚未测量过体内SCN中VIP的释放情况。在此，利用SCN微透析来研究调节VIP的机制。处于14:10明暗周期的仓鼠在接近中午时突触VIP释放出现每日峰值。在持续黑暗条件下，这种输出是无节律的。光和谷氨酸能激动剂N-甲基-D-天冬氨酸在夜间刺激VIP释放，而5-羟色胺（1A,7）激动剂（±）8-羟基-2-（二正丙基氨基）四氢萘氢溴酸盐在中午抑制释放。因此，SCN中VIP的活性受光信号输入刺激，并受5-羟色胺抑制。
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