两种共病的故事：理解抑郁和疼痛的神经生物学。
A tale of two comorbidities: Understanding the neurobiology of depression and pain.
机构信息
Research and Scientific Initiatives, Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine.
出版信息
Indian J Psychiatry. 2010 Apr;52(2):127-30. doi: 10.4103/0019-5545.64586.
Abstract
The comorbidity of chronic pain and depression has been consistently associated with a poor prognosis and greater disability in patients as compared to those suffering from each illness alone. This further has implications on significant financial costs to the patients and to our society. The biological underpinnings of major depression and chronic pain have considerable overlap in the areas of genetic, structural, functional, neuroendocrine and neurotransmitter functionality. Although the field has evolved in the past decade, more efforts should now focus on understanding the biological underpinnings of this shared comorbidity, while shedding light on treatment implications for these two devastating conditions.
摘要
慢性疼痛和抑郁症的共病与患者的预后不良和残疾程度增加有关，与单独患有每种疾病的患者相比更为明显。这进一步对患者和我们的社会造成了巨大的经济成本。重度抑郁症和慢性疼痛的生物学基础在遗传、结构、功能、神经内分泌和神经递质功能等方面有相当多的重叠。尽管该领域在过去十年中取得了进展，但现在应该更加努力地理解这种共同共病的生物学基础，同时阐明这两种破坏性疾病的治疗意义。
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