一些席夫碱金属配合物的合成、表征及杀菌活性
Synthesis, characterization and biocidal activities of some schiff base metal complexes.
作者信息
Neelakantan M A, Esakkiammal M, Mariappan S S, Dharmaraja J, Jeyakumar T
机构信息
Chemistry Research Centre, National Engineering College, K. R. Nagar, Kovilpatti-628 503, India.
出版信息
Indian J Pharm Sci. 2010 Mar;72(2):216-22. doi: 10.4103/0250-474X.65015.
Some new mixed ligand complexes (1-5) of type ML'B (M(II)=Mn(II), Co(II), Ni(II), Cu(II) and Zn(II); HL'= o-vanillidene-2-aminobenzothiazole; B= 1,10-phenanthroline) and Schiff base metal complexes of types (ML(2)") (6-10) and (M(2)L") (11-15) (HL"= o-vanillidene-2-amino-N-(2-pyridyl)-benzene sulfonamide) were synthesized and characterized by elemental analysis and spectral (IR, (1)H NMR and (13)C NMR) studies. The free ligands and their metal complexes have been screened for their in vitro biological activities against bacteria, fungi and yeast. The metal complexes show more potent activities compared with Schiff base ligands.
合成了一些新型混合配体配合物（1 - 5），其通式为ML'B（M(II)=Mn(II)、Co(II)、Ni(II)、Cu(II)和Zn(II)；HL'=邻香草醛 - 2 - 氨基苯并噻唑；B = 1,10 - 菲咯啉）以及席夫碱金属配合物（ML₂"）（6 - 10）和（M₂L"）（11 - 15）（HL"=邻香草醛 - 2 - 氨基 - N - (2 - 吡啶基) - 苯磺酰胺），并通过元素分析和光谱（红外光谱、¹H NMR和¹³C NMR）研究对其进行了表征。对游离配体及其金属配合物针对细菌、真菌和酵母的体外生物活性进行了筛选。与席夫碱配体相比，金属配合物显示出更强的活性。
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