Shobha Devi C, Thulasiram B, Aerva Rajeshwar Rao, Nagababu Penumaka
Department of Chemistry, RGUKT, Basar, Telangana State, India.
Inorganic & Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, Telangana State, 500007, India.
J Fluoresc. 2018 Sep;28(5):1195-1205. doi: 10.1007/s10895-018-2283-7. Epub 2018 Aug 31.
Copper is a part of various enzymes and helps them to function properly. It can be effectively used to produce promising anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as potential anticancer drugs. Herein, we briefly discuss the importance of reactive oxygen species in biological applications and copper(II) complexes as anticancer drugs. The anti-angiogenic properties of mono-nuclear copper(II) complexes have been demonstrated by in vivo chick embryo angiogenesis analysis. The plausible mechanism behind anticancer activity of these complexes is by the formation of excessive intracellular Reactive Oxygen Species (ROS). ROS is a composite term used for oxygen derivative non-radicals and free radicals of highly reactive components, that enhances the killing response of immune cells to microbial invasion. Previous reports have shown that ROS plays an important role as a messenger in cell cycling and normal cell signal transduction. Graphical Abstract The generation of singlet oxygen and healing the tumor cells with singlet oxygen in presence of UV-light.
铜是多种酶的组成部分，并有助于它们正常发挥功能。它可有效地用于生产有前景的抗癌药物，目前，全球正在进行许多关于开发基于铜的配合物作为潜在抗癌药物的研究。在此，我们简要讨论活性氧在生物应用中的重要性以及作为抗癌药物的铜（II）配合物。单核铜（II）配合物的抗血管生成特性已通过体内鸡胚血管生成分析得到证实。这些配合物抗癌活性背后的可能机制是通过形成过量的细胞内活性氧（ROS）。ROS是一个复合术语，用于表示氧衍生物非自由基和高反应性成分的自由基，它增强了免疫细胞对微生物入侵的杀伤反应。先前的报道表明，ROS在细胞周期和正常细胞信号转导中作为信使发挥重要作用。图形摘要：单线态氧的产生以及在紫外光存在下用单线态氧治愈肿瘤细胞。
