Department of Biological Chemistry, University of Athens Medical School, Athens, Greece.
Mol Med. 2011 Jan-Feb;17(1-2):36-40. doi: 10.2119/molmed.2010.00167. Epub 2010 Sep 8.
We compared the lipid profiles and serum levels of leptin, adiponectin and tumor necrosis factor-α (TNF-α) in rats with/without hyperlipidemia and with/without concomitant diabetes mellitus. Forty 10-wk-old male Wistar rats were divided into four groups. Groups A and C received standard food for 12 wks. Groups B and D received a high-fat diet enriched with 2% additional cholesterol. Moreover, insulin-deficient (type I) diabetes mellitus was induced in rats in groups C and D with intraperitoneal injections of streptozotocin. Fasting serum leptin levels were decreased in diabetic groups (groups C and D) compared with controls. Fasting serum adiponectin levels were decreased in groups C and D compared with group A. Serum TNF-α levels were augmented in groups B and D, those fed with an atherogenic diet. By contrast, TNF-α levels were decreased in group C. Our data suggest that serum leptin, adiponectin and TNF-α levels may serve as markers of obesity and type I diabetes mellitus.
我们比较了伴有/不伴有高脂血症以及伴有/不伴有并发糖尿病的大鼠的血脂谱和血清瘦素、脂联素和肿瘤坏死因子-α（TNF-α）水平。将 40 只 10 周龄雄性 Wistar 大鼠分为四组。A 组和 C 组接受标准食物 12 周。B 组和 D 组接受富含 2%额外胆固醇的高脂肪饮食。此外，用链脲佐菌素腹腔注射诱导 C 组和 D 组大鼠胰岛素缺乏（1 型）糖尿病。与对照组相比，糖尿病组（C 组和 D 组）空腹血清瘦素水平降低。与 A 组相比，C 组和 D 组空腹血清脂联素水平降低。B 组和 D 组（进食动脉粥样硬化饮食的组）血清 TNF-α 水平升高，而 C 组 TNF-α 水平降低。我们的数据表明，血清瘦素、脂联素和 TNF-α 水平可能是肥胖和 1 型糖尿病的标志物。
