Lithander Fiona E, Keogh Geraldine F, Wang Yu, Cooper Garth J S, Mulvey Tom B, Chan Yih-Kai, McArdle Brian H, Poppitt Sally D
Human Nutrition and Metabolic Unit, University of Auckland, Auckland, New Zealand.
Obesity (Silver Spring). 2008 Mar;16(3):592-9. doi: 10.1038/oby.2007.97. Epub 2008 Jan 17.
Little is known about the effects of alterations in fatty acid classes on adiponectin, a hormone secreted by the adipocyte known to be important in the development of diabetes and cardiovascular disease (CVD). Any factor, including diet, that may positively influence adiponectin gene expression or increase circulating levels might be useful for improving such metabolic abnormalities. We investigated the effects of alterations in dietary fatty acid saturation on fasting serum adiponectin and associated peptides.
Double-blind, randomized, crossover, 2 x 3-week residential intervention trial where 18 mildly hyperlipidemic adult men were provided with a high saturated:unsaturated fat (SFA:USFA) and lower SFA:USFA treatment separated by an uncontrolled 4-week washout. Only fatty acid profile was altered between treatments. Fasting blood samples were collected on days 0, 1, 7, 14, 21, 22 of each intervention period for the measurement of adiponectin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsC-RP), leptin, and ghrelin.
Body weight was kept constant (+/-1 kg) throughout each treatment. There was no detectable difference in fasting adiponectin at baseline (mean day 0 + day 1) between the treatment groups (mean +/- s.d.; high(SFA:USFA) = 7.0 +/- 1.7 vs. low(SFA:USFA) = 6.7 +/- 1.4 microg/ml, P > 0.05). There were neither significant between-treatment effects of fatty acid saturation (diet x time, P > 0.05) on serum adiponectin nor any significant between-treatment effects on serum TNF-alpha, IL-6, hsC-RP, leptin, or ghrelin (P > 0.05).
Fasting serum adiponectin was not detectably affected by alterations in dietary fatty acid profile in mildly hyperlipidemic men. There was no evidence that an increase in SFA content of the diet significantly worsened fasting serum adiponectin over a 3-week intervention period.
脂肪酸类别改变对脂联素的影响鲜为人知，脂联素是一种由脂肪细胞分泌的激素，已知在糖尿病和心血管疾病（CVD）的发展中起重要作用。任何可能对脂联素基因表达产生积极影响或增加循环水平的因素，包括饮食，都可能有助于改善此类代谢异常。我们研究了饮食脂肪酸饱和度改变对空腹血清脂联素及相关肽的影响。
双盲、随机、交叉、为期2个3周的住院干预试验，为18名轻度高脂血症成年男性提供高饱和脂肪酸：不饱和脂肪酸（SFA:USFA）饮食和低SFA:USFA饮食治疗，中间间隔4周无控制的洗脱期。各治疗组之间仅改变脂肪酸谱。在每个干预期的第0、1、7、14、21、22天采集空腹血样，用于检测脂联素、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、高敏C反应蛋白（hsC-RP）、瘦素和胃泌素。
在每个治疗期间，体重均保持恒定（±1kg）。治疗组之间在基线时（第0天和第1天的平均值）空腹脂联素无显著差异（平均值±标准差；高SFA:USFA组=7.0±1.7 vs.低SFA:USFA组=6.7±1.4μg/ml，P>0.05）。脂肪酸饱和度的治疗组间效应（饮食×时间，P>0.05）对血清脂联素无显著影响，对血清TNF-α、IL-6、hsC-RP、瘦素或胃泌素也无显著治疗组间效应（P>0.05）。
轻度高脂血症男性的饮食脂肪酸谱改变未对空腹血清脂联素产生明显影响。没有证据表明在3周的干预期内，饮食中SFA含量的增加会显著恶化空腹血清脂联素。
