Galler Angela, Gelbrich Götz, Kratzsch Jürgen, Noack Nicole, Kapellen Thomas, Kiess Wieland
University Hospital for Children and Adolescents, University of Leipzig, Oststr. 21-25, D-04317 Leipzig, Germany.
Eur J Endocrinol. 2007 Oct;157(4):481-9. doi: 10.1530/EJE-07-0250.
Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type 1 diabetes in a longitudinal manner and to study the impact of age, gender, body mass index (BMI) and metabolic control.
In this study, 88 children and adolescents with type 1 diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids. Healthy children (n = 259) were chosen as a control group.
Serum adiponectin levels were significantly higher in children with type 1 diabetes compared with healthy children (13.1 vs 9.1 microg/ml at baseline, P < 0.001). Adiponectin concentrations inversely correlated with BMI s.d.s (P < 0.001). No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Adiponectin concentrations decreased in males with type 1 diabetes during puberty (P = 0.03) while there was no significant change in females. In a subgroup of patients with new onset type 1 diabetes, adiponectin concentrations were not different from adiponectin levels in control subjects but increased during follow-up (P = 0.007). Stepwise multiple regression analysis showed that most important predictors of adiponectin levels in type 1 diabetes at the end of the study were adiponectin concentration at baseline (beta = 0.574, P < 0.001) and BMI s.d.s (beta = -0.302, P = 0.001, r2 = 0.56).
Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children.
脂联素在肥胖、2型糖尿病和心血管疾病的病理生理学中发挥重要作用。本研究的目的是以纵向方式测定1型糖尿病儿童和青少年的脂联素浓度，并研究年龄、性别、体重指数（BMI）和代谢控制的影响。
在本研究中，对88名1型糖尿病儿童和青少年进行了纵向随访。在基线和随访期间，通过酶联免疫吸附测定法测量血清脂联素水平，并将其与临床数据、糖化血红蛋白（HbA1c）和血脂相关联。选择健康儿童（n = 259）作为对照组。
与健康儿童相比，1型糖尿病儿童的血清脂联素水平显著更高（基线时为13.1 vs 9.1 μg/ml，P < 0.001）。脂联素浓度与BMI标准差呈负相关（P < 0.001）。在性别、糖尿病病程或HbA1c方面，脂联素水平无显著差异。1型糖尿病男性在青春期脂联素浓度下降（P = 0.03），而女性无显著变化。在新诊断的1型糖尿病患者亚组中，脂联素浓度与对照组无差异，但在随访期间升高（P = 0.007）。逐步多元回归分析表明，研究结束时1型糖尿病患者脂联素水平的最重要预测因素是基线时的脂联素浓度（β = 0.574，P < 0.001）和BMI标准差（β = -0.302，P = 0.001，r2 = 0.56）。
与健康儿童相比，1型糖尿病儿童和青少年的血清脂联素浓度因BMI升高而升高。
