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急诊动脉内取栓治疗大脑中动脉栓塞:文献复习及两则典型病例报告。

Emergency embolectomy for embolic occlusion of the middle cerebral artery-review of the literature and two illustrative cases.

机构信息

Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, Germany.

出版信息

Neurosurg Rev. 2011 Jan;34(1):21-8. doi: 10.1007/s10143-010-0283-4. Epub 2010 Sep 14.

DOI:10.1007/s10143-010-0283-4
PMID:20838840
Abstract

With the increasing number of endovascular interventions during the last years, the number of procedure-related complications has risen accordingly. Despite sophisticated and effective endovascular treatments for acute thromboembolic events during intervention, vessel occlusion can remain refractory to medical and endovascular treatment. In case of failure of the endovascular revascularisation, microsurgical embolectomy in the anterior circulation can be a last therapeutic option, if case selection is adequate. To date, this rather aggressive form of treatment is still controversial, and there are only few series of reported surgical embolectomy. In the present review, we conducted a Medline (www.pubmed.org) search for reports or studies of microsurgical embolectomies using the keywords (1) middle cerebral artery (MCA) occlusion and (2) embolectomy. The most relevant factors for positive outcome were concluded as such: (1) vessel occlusion time, (2) collateral flow, (3) occlusion site and (4) thromboembolic origin. Additionally, we report on two illustrative cases from our department with acute MCA occlusion treated by emergency microsurgical embolectomy but with very contrary outcomes. Hence, emergency embolectomy in patients with MCA occlusion following endovascular treatment can be quite effective, if endovascular recanalisation options fail. Nevertheless, the decision-making process must be made critically, fast and based on factors such as vessel occlusion time, sufficient collateral flow, occlusion site and thrombus origin.

摘要

近年来,血管内介入治疗的数量不断增加,与之相关的并发症数量也相应增加。尽管在介入治疗中针对急性血栓栓塞事件有复杂且有效的血管内治疗方法,但血管闭塞仍然可能对药物和血管内治疗产生抵抗。如果血管内再通治疗失败,在前循环中进行显微血管切除术可能是最后的治疗选择,如果病例选择适当的话。到目前为止,这种相当激进的治疗方式仍然存在争议,而且只有少数报道的手术取栓系列。在本综述中,我们使用关键词(1)大脑中动脉(MCA)闭塞和(2)取栓术,在 Medline(www.pubmed.org)上进行了检索,以查找使用显微血管切除术治疗的报告或研究。得出的阳性结果的最相关因素如下:(1)血管闭塞时间,(2)侧支循环,(3)闭塞部位和(4)血栓栓塞起源。此外,我们还报告了我们科室的两例急性 MCA 闭塞患者,他们接受了紧急显微血管切除术治疗,但结果却截然不同。因此,如果血管内再通治疗失败,急性 MCA 闭塞患者的紧急取栓术可能非常有效。然而,决策过程必须严格、快速,并基于血管闭塞时间、充足的侧支循环、闭塞部位和血栓起源等因素。

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Neurosurgery. 2009 Dec;65(6):E1191-4; discussion E1194. doi: 10.1227/01.NEU.0000351783.00831.BB.
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Outcome predictors of open embolectomy in middle cerebral artery occlusion.大脑中动脉闭塞行开放性取栓术的预后预测因素
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The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism.
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Neurosurg Rev. 2015 Jan;38(1):49-57; discussion 57. doi: 10.1007/s10143-014-0570-6. Epub 2014 Aug 30.
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BMJ Case Rep. 2013 Apr 22;2013:bcr2012010646. doi: 10.1136/bcr-2012-010646.
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AJNR Am J Neuroradiol. 2008 Aug;29(7):1409-13. doi: 10.3174/ajnr.A1110. Epub 2008 May 22.
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