Department of Neurosurgery, University of Utah, Salt Lake City, UT, United States.
Department of Neurosurgery, University of Utah, Salt Lake City, UT, United States.
Handb Clin Neurol. 2020;169:137-150. doi: 10.1016/B978-0-12-804280-9.00009-3.
Meningiomas are the most common primary intracranial brain tumor in adult humans; however, our understanding of meningioma tumorigenesis is relatively limited in comparison with the body of research available for other intracranial tumors such as gliomas. Here we briefly describe the current understanding of aberrant signaling pathways and tumor growth mechanisms responsible for meningioma differentiation, cellular growth, development, inhibition, and death. Numerous cellular functions impacted by these signaling pathways are critical for angiogenesis, proliferation, and apoptosis. Ultimately, a further understanding of the signaling pathways involved in meningioma tumorigenesis will lead to better treatment modalities in the future.
脑膜瘤是成人原发性颅内脑肿瘤中最常见的一种；然而，与其他颅内肿瘤（如神经胶质瘤）相比，我们对脑膜瘤发生的理解相对有限。在这里，我们简要描述了目前对导致脑膜瘤分化、细胞生长、发育、抑制和死亡的异常信号通路和肿瘤生长机制的理解。这些信号通路所影响的许多细胞功能对血管生成、增殖和凋亡至关重要。最终，对脑膜瘤发生中涉及的信号通路的进一步理解将导致未来更好的治疗方式。
