Siracusa Carlo, Manteca Xavier, Cuenca Rafaela, del Mar Alcalá Maria, Alba Aurora, Lavín Santiago, Pastor Josep
Department of Animal Medicine and Surgery, School of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain.
J Am Vet Med Assoc. 2010 Sep 15;237(6):673-81. doi: 10.2460/javma.237.6.673.
To study the effects of a synthetic, dog-appeasing pheromone (sDAP) on the behavioral, neuroendocrine, immune, and acute-phase perioperative stress responses in dogs undergoing elective orchiectomy or ovariohysterectomy.
Randomized, controlled clinical trial.
46 dogs housed in animal shelters and undergoing elective orchiectomy or ovariohysterectomy.
Intensive care unit cages were sprayed with sDAP solution or sham treated with the carrier used in the solution 20 minutes prior to use. Dogs (n = 24 and 22 in the sDAP and sham treatment exposure groups, respectively) were placed in treated cages for 30 minutes before and after surgery. Indicators of stress (ie, alterations in behavioral, neuroendocrine, immune, and acute-phase responses) were evaluated perioperatively. Behavioral response variables, salivary cortisol concentration, WBC count, and serum concentrations of glucose, prolactin, haptoglobin, and C-reactive protein were analyzed.
Behavioral response variables and serum prolactin concentration were influenced by sDAP exposure. Dogs exposed to sDAP were more likely to have alertness and visual exploration behaviors after surgery than were dogs exposed to sham treatment. Decreases in serum prolactin concentrations in response to perioperative stress were significantly smaller in dogs exposed to sDAP, compared with findings in dogs exposed to the sham treatment. Variables examined to evaluate the hypothalamic-pituitary-adrenal axis, immune system, and acute-phase responses were unaffected by treatment.
sDAP appeared to affect behavioral and neuroendocrine perioperative stress responses by modification of lactotropic axis activity. Use of sDAP in a clinical setting may improve the recovery and welfare of dogs undergoing surgery.
研究一种合成的犬安抚信息素（sDAP）对接受择期睾丸切除术或卵巢子宫切除术的犬的行为、神经内分泌、免疫和急性期围手术期应激反应的影响。
随机对照临床试验。
46只饲养在动物收容所且接受择期睾丸切除术或卵巢子宫切除术的犬。
在重症监护病房的笼子使用前20分钟，用sDAP溶液喷洒或用溶液中的载体进行假处理。犬（sDAP和假处理暴露组分别为24只和22只）在手术前后置于处理过的笼子中30分钟。围手术期评估应激指标（即行为、神经内分泌、免疫和急性期反应的改变）。分析行为反应变量、唾液皮质醇浓度、白细胞计数以及葡萄糖、催乳素、触珠蛋白和C反应蛋白的血清浓度。
行为反应变量和血清催乳素浓度受sDAP暴露影响。与接受假处理的犬相比，暴露于sDAP的犬术后更可能出现警觉和视觉探索行为。与接受假处理的犬相比，暴露于sDAP的犬因围手术期应激导致的血清催乳素浓度降低明显更小。用于评估下丘脑 - 垂体 - 肾上腺轴、免疫系统和急性期反应的变量不受处理影响。
sDAP似乎通过改变促乳素轴活性影响行为和神经内分泌围手术期应激反应。在临床环境中使用sDAP可能改善接受手术犬的恢复情况和健康状况。
