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人类皮肤微生物组与蚊子相互作用的化学生态学。

Chemical ecology of interactions between human skin microbiota and mosquitoes.

机构信息

Laboratory of Entomology, Wageningen University and Research Centre, Wageningen, The Netherlands.

出版信息

FEMS Microbiol Ecol. 2010 Oct;74(1):1-9. doi: 10.1111/j.1574-6941.2010.00908.x.

DOI:10.1111/j.1574-6941.2010.00908.x
PMID:20840217
Abstract

Microbiota on the human skin plays a major role in body odour production. The human microbial and chemical signature displays a qualitative and quantitative correlation. Genes may influence the chemical signature by shaping the composition of the microbiota. Recent studies on human skin microbiota, using 16S rRNA gene sequencing, found a high inter- and intrapersonal variation in bacterial species on the human skin, which is relatively stable over time. Human body odours mediate the attraction of mosquitoes to their blood hosts. Odours produced by skin microbiota are attractive to mosquitoes as shown by in vitro studies, and variation in bacterial species on the human skin may explain the variation in mosquito attraction between humans. Detailed knowledge of the ecology and genetics of human skin microbiota is needed in order to unravel the evolutionary mechanisms that underlie the interactions between mosquitoes and their hosts.

摘要

人体皮肤上的微生物群在体味产生中起着重要作用。人类微生物和化学特征显示出定性和定量的相关性。基因可能通过塑造微生物群的组成来影响化学特征。最近使用 16S rRNA 基因测序对人体皮肤微生物群进行的研究发现,人体皮肤上细菌种类的个体间和个体内差异很大,而且随着时间的推移相对稳定。人体气味介导蚊子对其血液宿主的吸引力。体外研究表明,皮肤微生物群产生的气味对蚊子有吸引力,而人体皮肤上细菌种类的变化可能解释了蚊子对人类的吸引力的变化。为了解开蚊子与其宿主之间相互作用的进化机制,需要详细了解人体皮肤微生物群的生态和遗传学。

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