Gynaecological Endocrinology Unit, Paris Descartes University, Paris, France.
Ann N Y Acad Sci. 2010 Sep;1205:268-76. doi: 10.1111/j.1749-6632.2010.05664.x.
Following the Women's Health Initiative (WHI) publication in mid 2002, a drastic decrease in hormone therapy for postmenopausal women has been observed worldwide. Since 2007, the reported incidence in breast cancer has declined. Most authors have linked this decline to the reduction in hormone treatment. In this paper we discuss why these ecological observations are not fully convincing and focus on the importance of screening and variations in other risk factors to interpret this decline in breast cancer.
2002 年年中《妇女健康倡议》（WHI）发表后，全世界范围内绝经后妇女使用激素疗法的情况急剧减少。自 2007 年以来，乳腺癌的报告发病率有所下降。大多数作者将这一下降与激素治疗的减少联系起来。在本文中，我们讨论了为什么这些生态观察结果并不完全令人信服，并重点讨论了筛查的重要性以及其他风险因素的变化，以解释乳腺癌发病率的下降。
