Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
J Vet Intern Med. 2010 Nov-Dec;24(6):1314-21. doi: 10.1111/j.1939-1676.2010.0598.x. Epub 2010 Sep 14.
Clinical remission is frequent in cats with well-controlled diabetes mellitus, but few studies explored predictors of this phenomenon.
Data retrieved from medical records at admission might be valuable to identify likelihood of remission and its duration in diabetic cats.
Ninety cats with newly diagnosed diabetes, followed-up until death or remission.
Retrospective cohort study. Data were collected from records at admission, including history, signalment, physical examination, haematology, and biochemical profile, and the occurrence and duration of remission, defined as normoglycemia without insulin for ≥4 weeks. Predictors of remission were studied with univariate and multivariate logistic regression. Factors associated with remission duration were analyzed with Kaplan-Meier and Cox proportional hazard models.
Forty-five (50%) cats achieved remission, after a median time of 48 days (range: 8-216). By study end, median remission duration was 114 days (range: 30-3,370) in cats that died and 151 days (range: 28-1,180) in alive cats. Remission was more likely with higher age (OR: 1.23, 95% CI: 1.04-1.46; P=.01) and less likely with increased serum cholesterol (OR: 0.36, 95% CI: 0.11-0.87; P=.04). Remission was longer with higher body weight (HR: 0.65, 95% CI: 0.42-0.99; P=.04) and shorter with higher blood glucose (HR: 1.01, 95% CI: 1.00-1.02; P=.02).
Age, body weight, cholesterol, and glucose levels are suggested for prediction of remission or its duration in diabetic cats. Older cats developing diabetes may have a better outcome, possibly suggesting a slower disease progression.
患有糖尿病且病情得到良好控制的猫常出现临床缓解，但很少有研究探索这种现象的预测因素。
入院时从病历中获取的数据可能有助于识别糖尿病猫缓解的可能性及其持续时间。
90 只新诊断为糖尿病的猫，随访至死亡或缓解。
回顾性队列研究。从入院记录中收集数据，包括病史、品种、体格检查、血液学和生化特征，以及缓解的发生和持续时间，定义为无胰岛素治疗血糖正常≥4 周。使用单变量和多变量逻辑回归研究缓解的预测因素。使用 Kaplan-Meier 和 Cox 比例风险模型分析与缓解持续时间相关的因素。
45 只（50%）猫达到缓解，中位数时间为 48 天（范围：8-216）。研究结束时，死亡猫的中位缓解持续时间为 114 天（范围：30-3370），存活猫为 151 天（范围：28-1180）。年龄较大（OR：1.23，95%CI：1.04-1.46；P=.01）和血清胆固醇升高（OR：0.36，95%CI：0.11-0.87；P=.04）的猫更有可能缓解。体重较高（HR：0.65，95%CI：0.42-0.99；P=.04）和血糖较高（HR：1.01，95%CI：1.00-1.02；P=.02）的猫缓解时间更长。
年龄、体重、胆固醇和血糖水平可用于预测糖尿病猫的缓解或其持续时间。患有糖尿病的老年猫可能有更好的预后，这可能表明疾病进展较慢。
