德国糖尿病猫的一般情况和实验室检查结果：对 129505 例猫的实验室送检结果进行的回顾性分析。
Signalment and laboratory findings in cats with diabetes mellitus in Germany: a retrospective review of laboratory submissions of 129,505 cats.
机构信息
Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig-University Giessen, Germany.
Antech Lab Germany GmbH, Augsburg, Germany.
出版信息
J Feline Med Surg. 2024 Sep;26(9):1098612X241262669. doi: 10.1177/1098612X241262669.
OBJECTIVES
The aims of this study were to compare signalment and laboratory parameters between diabetic (D) and non-diabetic (ND) cats and poorly-controlled diabetic (PD) and well-controlled diabetic (WD) cats in Germany.
METHODS
Laboratory data from Antech Lab Germany between 2015 and 2018 were retrospectively analysed. Age, sex, red blood cell count (RBC), creatinine (CREA), alkaline phosphatase (AP), alanine aminotransferase (ALT), bilirubin (BILI), cholesterol (CHOL), triglycerides (TRI), glucose (GLU) and total thyroxine (TT4) were compared between D (fructosamine ⩾340 µmol/l) and ND cats, and PD (fructosamine >500 µmol/l) and WD (fructosamine 340-500 µmol/l) cats. The proportion of cats with anaemia (RBC ⩽4.21 ×10/l), CREA >250 µmol/l, ALT >455 U/l, AP >315 U/l, BILI ⩾35 µmol/l and TT4 > reference interval (RI) was compared between PD and WD cats. Data are presented as median and interquartile range (IQR) and analysed using non-parametric tests. Significance was <0.05, and effect size was assessed by Cramér V or r.
RESULTS
In total, 129,505 cats were included (D: n = 9334 [prevalence 7.2%], WD: n = 5670/9334 [60.7%]). The median age of D and ND cats was 12 years (IQR D 9-14; ND 9-15); there was no difference in sex. A significant difference was found between groups (D vs ND; PD vs WD) for all parameters studied. Considering the effect sizes and medians outside the RI, the only relevant difference was higher CHOL, TRI, AP and GLU in PD compared with WD (CHOL: PD 7.46 [5.85-9.32] vs WD 5.44 [4.32-6.97] mmol/l, <0.001, r = 0.39; TRI: PD 1.44 [0.84-3.66] vs WD 0.78 [0.5-1.35] mmol/l, <0.001, r = 0.35; AP: PD 66 [47-92] vs WD 35 [23-59] U/l, <0.001, r = 0.39; GLU: PD 23.7 [20.15-27.3] vs WD 6.89 [5-11.31] mmol/l, <0.001, r = 0.69).
CONCLUSIONS AND RELEVANCE
Laboratory changes in diabetic cats were mild and mainly associated with lipid derangements.
目的
本研究旨在比较德国糖尿病（D）和非糖尿病（ND）猫以及血糖控制不佳（PD）和血糖控制良好（WD）糖尿病猫的一般情况和实验室参数。
方法
回顾性分析 2015 年至 2018 年期间 Antech 德国实验室的数据。比较 D（果糖胺≥340μmol/L）和 ND 猫以及 PD（果糖胺>500μmol/L）和 WD（果糖胺 340-500μmol/L）猫的年龄、性别、红细胞计数（RBC）、肌酐（CREA）、碱性磷酸酶（AP）、丙氨酸氨基转移酶（ALT）、胆红素（BILI）、胆固醇（CHOL）、三酰甘油（TRI）、血糖（GLU）和总甲状腺素（TT4）。比较 PD 和 WD 猫的贫血（RBC≤4.21×10/l）、CREA>250μmol/L、ALT>455U/L、AP>315U/L、BILI≥35μmol/L 和 TT4>参考区间（RI）的比例。数据以中位数和四分位距（IQR）表示，并使用非参数检验进行分析。P 值<0.05，效应大小由 Cramér V 或 r 评估。
结果
共纳入 129505 只猫（D：n=9334[患病率 7.2%]，WD：n=5670/9334[60.7%]）。D 和 ND 猫的中位年龄为 12 岁（IQR D 9-14；ND 9-15）；性别无差异。所有研究参数在组间（D 与 ND；PD 与 WD）均存在显著差异。考虑到效应大小和 RI 外的中位数，唯一相关的差异是 PD 组的 CHOL、TRI、AP 和 GLU 高于 WD 组（CHOL：PD 7.46[5.85-9.32] vs WD 5.44[4.32-6.97]mmol/L，<0.001，r=0.39；TRI：PD 1.44[0.84-3.66] vs WD 0.78[0.5-1.35]mmol/L，<0.001，r=0.35；AP：PD 66[47-92] vs WD 35[23-59]U/L，<0.001，r=0.39；GLU：PD 23.7[20.15-27.3] vs WD 6.89[5-11.31]mmol/L，<0.001，r=0.69）。
结论和相关性
糖尿病猫的实验室变化是轻微的，主要与脂质紊乱有关。
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