Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.
J Vet Intern Med. 2010 Nov-Dec;24(6):1329-36. doi: 10.1111/j.1939-1676.2010.0595.x. Epub 2010 Sep 14.
Urinary catecholamines and metanephrines have been proposed as a diagnostic tool for identifying canine pheochromocytomas, but the effects of critical illness on urine concentrations of catecholamines and metanephrines currently are unknown.
To examine the effects of illness on urine concentrations of catecholamines and metanephrines in dogs.
Twenty-five critically ill dogs and 25 healthy age- and sex-matched control dogs.
Prospective observational study. Urine was collected from healthy and critically ill dogs, and urine concentrations of epinephrine, norepinephrine, metanephrine, and normetanephrine were measured by high-performance liquid chromatography with electrochemical detection. Urinary catecholamine and metanephrine:creatinine ratios were calculated and compared between groups.
Urinary epinephrine, norepinephrine, metanephrine, and normetanephrine:creatinine ratios were higher in critically ill dogs when compared with a healthy control population (P=.0009, P<0.0001, P<0.0001, and P<0.0001, respectively).
Illness has a significant impact on urinary catecholamines and their metabolites in dogs. Further investigation of catecholamine and metanephrine concentrations in dogs with pheochromocytomas is warranted to fully evaluate this test as a diagnostic tool; however, the findings of this study suggest that the results may be difficult to interpret in dogs with concurrent illness.
尿儿茶酚胺和甲氧基肾上腺素已被提议作为识别犬嗜铬细胞瘤的诊断工具，但目前尚不清楚危重病对儿茶酚胺和甲氧基肾上腺素尿液浓度的影响。
研究疾病对犬尿液中儿茶酚胺和甲氧基肾上腺素浓度的影响。
25 只危重病犬和 25 只年龄和性别匹配的健康对照犬。
前瞻性观察性研究。从健康和危重病犬中采集尿液，并通过高效液相色谱法电化学检测测量尿液中肾上腺素、去甲肾上腺素、甲氧基肾上腺素和间甲氧基肾上腺素的浓度。计算并比较两组间尿儿茶酚胺和甲氧基肾上腺素：肌酐比值。
与健康对照组相比，危重病犬的尿肾上腺素、去甲肾上腺素、甲氧基肾上腺素和间甲氧基肾上腺素：肌酐比值均升高（P 值分别为 0.0009、<0.0001、<0.0001 和 <0.0001）。
疾病对犬的尿液儿茶酚胺及其代谢物有显著影响。需要进一步研究嗜铬细胞瘤犬的儿茶酚胺和甲氧基肾上腺素浓度，以充分评估该检测作为诊断工具的价值；然而，本研究的结果表明，在伴有合并症的犬中，结果可能难以解释。
