Westermann R, Grothe C, Unsicker K
Department of Anatomy and Cell Biology, Philipps University, Marburg, Fed. Rep. Germany.
J Cell Sci Suppl. 1990;13:97-117. doi: 10.1242/jcs.1990.supplement_13.10.
Basic fibroblast growth factor (bFGF), a heparin-binding mitogen for mesoderm-derived cells, also acts as a mitogen, differentiation inducing and maintenance factor for many neuroectodermal cells including glial cells, neurons, paraneurons, and their tumor counterparts. The molecule is expressed in several types of neuroectodermal cells in vitro and in vivo. Furthermore, bFGF occurs in many neuronal target tissues, and can prevent ontogenetic as well as lesion-induced neuron death. Thus, in terms of its wide range of functions, bFGF is apparently more than a 'classical' neurotrophic factor. Some of its essential features, such as regulation of expression, local availability and transport in the nervous system remain to be studied.
碱性成纤维细胞生长因子（bFGF）是一种中胚层来源细胞的肝素结合有丝分裂原，它还可作为有丝分裂原、分化诱导因子和维持因子，作用于许多神经外胚层细胞，包括神经胶质细胞、神经元、副神经元及其肿瘤对应细胞。该分子在体外和体内的多种神经外胚层细胞中均有表达。此外，bFGF存在于许多神经元靶组织中，并且可以预防个体发育过程中以及损伤诱导的神经元死亡。因此，就其广泛的功能而言，bFGF显然不仅仅是一种“经典的”神经营养因子。其一些基本特征，如在神经系统中的表达调控、局部可用性和运输等仍有待研究。
