Yang Fan, Tang Dongming, Bai Yong, Zhao Mingyuan, Zhu Qingxin
School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Aug;27(4):924-8.
Multiple sequence alignment is one of the basic techniques in bioinformatics, and it plays a vital role in structure modeling, functional site prediction, and phylogenetic analysis. In this paper, we review the methodologies and recent advances in the multiple protein sequence alignment, e.g., speeding up the calculation of distances among sequences and employing the iterative refinement and consistency-based scoring function, with emphasis on the use of additional sequence and structural information for improving alignment quality.
多序列比对是生物信息学中的基本技术之一，在结构建模、功能位点预测和系统发育分析中起着至关重要的作用。本文综述了多蛋白序列比对的方法和最新进展，例如加快序列间距离的计算以及采用迭代优化和基于一致性的评分函数，重点介绍了利用额外的序列和结构信息来提高比对质量。
