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Regulation of the Apaf-1-caspase-9 apoptosome.

作者信息

Bratton Shawn B, Salvesen Guy S

机构信息

Division of Pharmacology and Toxicology, College of Pharmacy, and Center for Molecular and Cellular Toxicology, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712-0125, USA.

出版信息

J Cell Sci. 2010 Oct 1;123(Pt 19):3209-14. doi: 10.1242/jcs.073643.

Abstract
摘要

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本文引用的文献

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Structure of an apoptosome-procaspase-9 CARD complex.
Structure. 2010 May 12;18(5):571-83. doi: 10.1016/j.str.2010.04.001.
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tRNA binds to cytochrome c and inhibits caspase activation.
Mol Cell. 2010 Mar 12;37(5):668-78. doi: 10.1016/j.molcel.2010.01.023.
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p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress.
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The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.
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Control of mitochondrial apoptosis by the Bcl-2 family.
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The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
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DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine.
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Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias.
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