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假阳性率是否导致噪声性听力损失的高估?

Are false-positive rates leading to an overestimation of noise-induced hearing loss?

机构信息

University of Minnesota, Minneapolis, USA.

出版信息

J Speech Lang Hear Res. 2011 Apr;54(2):679-92. doi: 10.1044/1092-4388(2010/09-0132). Epub 2010 Sep 15.

DOI:10.1044/1092-4388(2010/09-0132)
PMID:20844255
Abstract

PURPOSE

To estimate false-positive rates for rules proposed to identify early noise-induced hearing loss (NIHL) using the presence of notches in audiograms.

METHOD

Audiograms collected from school-age children in a national survey of health and nutrition (the Third National Health and Nutrition Examination Survey [NHANES III]; National Center for Health Statistics, 1994) were examined using published rules for identifying noise notches at various pass-fail criteria. These results were compared with computer-simulated "flat" audiograms. The proportion of these identified as having a noise notch is an estimate of the false-positive rate for a particular rule.

RESULTS

Audiograms from the NHANES III for children 6-11 years of age yielded notched audiograms at rates consistent with simulations, suggesting that this group does not have significant NIHL. Further, pass-fail criteria for rules suggested by expert clinicians, applied to NHANES III audiometric data, yielded unacceptably high false-positive rates.

CONCLUSIONS

Computer simulations provide an effective method for estimating false-positive rates for protocols used to identify notched audiograms. Audiometric precision could possibly be improved by (a) eliminating systematic calibration errors, including a possible problem with reference levels for TDH-style earphones; (b) repeating and averaging threshold measurements; and (c) using earphones that yield lower variability for 6.0 and 8.0 kHz--2 frequencies critical for identifying noise notches.

摘要

目的

使用听力图中的切迹来评估识别早期噪声性听力损失(NIHL)的规则所产生的假阳性率。

方法

使用发表的规则,根据不同的通过/失败标准,对来自全国健康和营养调查(第三次全国健康和营养检查调查[NHANES III];国家健康统计中心,1994 年)的学龄儿童的听力图进行检查,以识别噪声切迹。将这些结果与计算机模拟的“平坦”听力图进行比较。识别为具有噪声切迹的比例是特定规则的假阳性率的估计值。

结果

NHANES III 中 6-11 岁儿童的听力图产生了与模拟一致的切迹听力图,这表明该组没有明显的 NIHL。此外,应用于 NHANES III 听力数据的专家临床医生建议的规则的通过/失败标准产生了不可接受的高假阳性率。

结论

计算机模拟为识别切迹听力图的协议提供了估计假阳性率的有效方法。通过以下方法可以提高听力计的精度:(a)消除系统校准误差,包括 TDH 样式耳机参考水平的可能问题;(b)重复和平均阈值测量;(c)使用可产生更低的 6.0 和 8.0 kHz 变异性的耳机-识别噪声切迹的两个关键频率。

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