Marr Brian, Gobin Pierre Y, Dunkel Ira J, Brodie Scott E, Abramson David H
Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Middle East Afr J Ophthalmol. 2010 Jul;17(3):207-9. doi: 10.4103/0974-9233.65492.
To describe an unusual clinical finding seen in children undergoing intra-arterial chemotherapy for retinoblastoma.
A retrospective review of 69 eyes of 63 patients receiving intra-arterial chemotherapy over a 3-year period. Charts and photographs of 69 consecutive cases were reviewed, and data were collected on patients with clinical evidence of a hyperemic cutaneous periocular abnormality following the procedure.
A blanching erythematous and edematous patch was noted in the periocular region in 16% (11 of 69) of the children who received intraarterial chemotherapy. The plaque extended into the region of the supertrochlear and medial marginal artery distribution on the ipsilateral side of the intra-arterial chemotherapy. All patches of erythema spontaneously resolved within 3 months following completion of the intra-arterial chemotherapy.
Periocular erythema and swelling is a self-limited clinical finding associated with intra-arterial chemotherapy in a small number of patients.
描述视网膜母细胞瘤患儿在接受动脉内化疗时出现的一种不寻常的临床发现。
回顾性分析63例患者在3年期间接受动脉内化疗的69只眼睛。对69例连续病例的病历和照片进行了回顾，并收集了术后有眼部周围皮肤充血异常临床证据患者的数据。
在接受动脉内化疗的儿童中，16%（69例中的11例）在眼周区域出现苍白性红斑和水肿斑。斑块扩展至动脉内化疗同侧的滑车上动脉和内眦动脉分布区域。所有红斑斑在动脉内化疗完成后的3个月内均自行消退。
眼周红斑和肿胀是少数患者动脉内化疗相关的自限性临床发现。
