Kandalam Mallikarjuna, Mitra Moutushy, Subramanian Krishnakumar, Biswas Jyotirmay
Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Middle East Afr J Ophthalmol. 2010 Jul;17(3):217-23. doi: 10.4103/0974-9233.65498.
Retinoblastoma (RB) is an embryonic neoplasm of retinal origin. For many years, scientists have sought the fundamental origins of tumorigenesis, with the ultimate hope of discovering a cure. Indeed, these efforts have led to a significant understanding that multiple molecular and genetic aberrations, such as uncontrolled proliferation and the inhibition of apoptosis that contribute to the canonical characteristics of tumor biology. Despite these advances, a thorough understanding, such as the precise cells, which are the targets of neoplastic transformation, especially in solid tumors, is currently lacking. The focus of this review is to emphasize the molecular defects involved in the RB tumor progression and mechanisms associated with inhibition of tumor cell apoptotic processes. This review also discusses the importance of target molecules characterization and their potential therapeutic or prognostic use in RB disease.
视网膜母细胞瘤（RB）是一种起源于视网膜的胚胎性肿瘤。多年来，科学家们一直在探寻肿瘤发生的根本起源，最终希望找到治愈方法。事实上，这些努力已带来了重大认识，即多种分子和基因异常，如不受控制的增殖和对凋亡的抑制，这些异常导致了肿瘤生物学的典型特征。尽管取得了这些进展，但目前仍缺乏对肿瘤转化靶点的确切细胞的全面理解，尤其是在实体瘤中。本综述的重点是强调RB肿瘤进展中涉及的分子缺陷以及与抑制肿瘤细胞凋亡过程相关的机制。本综述还讨论了靶分子特征描述的重要性及其在RB疾病中的潜在治疗或预后用途。
