White David, Beringer Timothy
Meadowlands Unit, Musgrave Park Hospital, Belfast BT9 7JB.
Ulster Med J. 2010 Jan;79(1):22-4.
We report a case of paraneoplastic limbic encephalitis (PLE) in an elderly lady with small-cell lung carcinoma (SCLC) and positive anti-RI neuronal auto-antibody. PLE is a relatively rare clinical entity associated with cancer patients, but is probably under-diagnosed. PLE typically presents clinically with affective changes in personality, cognitive dysfunction and seizures in a patient with malignancy, particularly SCLC. Although diagnosis does not rely upon definitive investigation results, serum paraneoplastic antibodies, abnormal CSF, and characteristic MRI and EEG findings may support the diagnosis. As PLE often presents prior to the discovery of a primary tumour, knowledge of the disease may assist in identifying underlying malignancy.
我们报告了一例老年女性患副肿瘤性边缘叶脑炎（PLE）的病例，该患者患有小细胞肺癌（SCLC）且抗RI神经元自身抗体呈阳性。PLE是一种与癌症患者相关的相对罕见的临床病症，但可能存在诊断不足的情况。PLE在临床上通常表现为恶性肿瘤患者，特别是SCLC患者出现人格情感变化、认知功能障碍和癫痫发作。虽然诊断并不依赖于明确的检查结果，但血清副肿瘤抗体、脑脊液异常以及特征性的MRI和脑电图检查结果可能有助于诊断。由于PLE常常在原发性肿瘤被发现之前出现，了解该疾病可能有助于识别潜在的恶性肿瘤。
