Marjani Abdoljalal, Gharanjik Aman Mohammad
1Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province Iran.
2Student Research Committee, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province Iran.
Indian J Clin Biochem. 2018 Apr;33(2):208-213. doi: 10.1007/s12291-017-0660-7. Epub 2017 May 26.
Cytochrome P450 2C9 (CYP2C9) is involved in metabolism of many important drugs and its genotype variations is thought to affect drug efficacy and the treatment process. The aim of this study was to assess the distribution of CYP2C9 allele and genotypic variants in Sistani ethnic group, living in Gorgan, South East of Caspian Sea and North East of Iran. This study included 140 Sistani, referred to the health center of Gorgan. CYP2C9 genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism technique. The allele frequency of CYP2C91, CYP2C92 and CYP2C93 was 76.1, 16.1 and 7.8%, respectively. The frequency of CYP2C91/1, CYP2C91/2, CYP2C91/3, CYP2C92/2, CYP2C92/3 and CYP2C93/*3 genotypes was 53.9, 22.1, 11.4, 2.9, 4.3% and nil, respectively. In this study the genotypic variations of the CYP2C9 allele among the Sistani ethnic group was investigated and great differences were observed in comparison to other populations. Our findings suggest that different genotypes of may influence the pharmacokinetics of some drugs. More studies on the pharmacokinetic effects of genotypes may help physicians choose optimal dosage of some drugs for treatment and prevention of their side effects. Since different ethnic groups from all over the world use medications, it suggests to investigate the pharmacokinetic effects of genotypes in different populations.
细胞色素P450 2C9（CYP2C9）参与多种重要药物的代谢，其基因分型变异被认为会影响药物疗效和治疗过程。本研究的目的是评估居住在里海东南部戈尔甘和伊朗东北部的锡斯坦尼族中CYP2C9等位基因和基因型变异的分布情况。本研究纳入了140名前往戈尔甘健康中心就诊的锡斯坦尼族人。采用聚合酶链反应-限制性片段长度多态性技术进行CYP2C9基因分型。CYP2C91、CYP2C92和CYP2C93的等位基因频率分别为76.1%、16.1%和7.8%。CYP2C91/1、CYP2C91/2、CYP2C91/3、CYP2C92/2、CYP2C92/3和CYP2C93/*3基因型的频率分别为53.9%、22.1%、11.4%、2.9%、4.3%和零。本研究调查了锡斯坦尼族人群中CYP2C9等位基因的基因型变异，并观察到与其他人群相比存在很大差异。我们的研究结果表明，[此处原文缺失具体基因名称]的不同基因型可能会影响某些药物的药代动力学。对[此处原文缺失具体基因名称]基因型的药代动力学效应进行更多研究，可能有助于医生选择某些药物的最佳剂量以进行治疗并预防其副作用。由于世界各地不同种族都使用药物，因此建议研究不同人群中[此处原文缺失具体基因名称]基因型的药代动力学效应。
