Université de Nantes, CNRS, Chimie et Interdisciplinarité: Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS 6230, Faculté des Sciences et des Techniques, BP 92208, 44322 Nantes, Cedex 3, France.
Chirality. 2010 Nov;22(10):864-9. doi: 10.1002/chir.20891.
This review deals with the preparation of chiral, nonracemic α-aminoorganostannanes and their applications in asymmetric synthesis. The pioneering works in this field date back almost 20 years ago and since then extensive research has been carried out to develop efficient and selective routes to highly enantioenriched α-aminoorganostannanes. The facile Sn/Li transmetalation of these compounds by n-BuLi has led to various applications in stereoselective synthesis. Selected examples using chiral α-aminoorganostannanes as starting materials will be reported.
这篇综述讨论了手性、非外消旋α-氨基有机锡烷的制备及其在不对称合成中的应用。该领域的开创性工作可以追溯到近 20 年前，此后，人们开展了广泛的研究，以开发高效、选择性的方法来制备高对映体纯的α-氨基有机锡烷。这些化合物通过 n-BuLi 易于进行 Sn/Li 交叉金属化反应，从而在立体选择性合成中得到了各种应用。本文将报道一些使用手性α-氨基有机锡烷作为起始原料的实例。
