Jin Y, Dehesdin D, Hemet J, Bagot D'arc C, Creissard P, Tadie M
Laboratoire de Chirurgie expérimentale, U.F.R. Médecine et Pharmacie de Rouen.
Neurochirurgie. 1990;36(6):378-82.
The respective possibilities of nerve reparation with classical microsutures or biological glue (bioglue) were compared on experimental rat sciatic nerve lesions. Seventy rats were operated upon, and 69 results can be interpreted. 22 had a microsuture, 47 anastomosis with bioglue (Tissucol). The animals were followed for 120 days, and the results assessed on muscular testing, electrostimulation, optic microscopic histology, and morphometry. Five anastomosis dysjunctions occurred in the bioglue group, because of technical errors. All other animals improved from the 60th day. From the histological view point, the results with bioglue were more satisfactory, because of the absence of foreign body reaction to sutures; the authors conclude that because of the equivalent results on nerve function, and better histological results with bioglue, its use is preferable to repair nerves, especially when microsuture is technically difficult.
在实验性大鼠坐骨神经损伤模型上，比较了经典显微缝合术与生物胶水（生物胶）修复神经的各自可能性。对70只大鼠进行了手术，69例结果可供分析。22例采用显微缝合，47例采用生物胶（纤维蛋白胶）吻合。对动物随访120天，并通过肌肉测试、电刺激、光学显微镜组织学和形态测量学对结果进行评估。生物胶组因技术失误发生了5例吻合口分离。所有其他动物从第60天起病情有所改善。从组织学角度来看，生物胶的结果更令人满意，因为不存在对缝线的异物反应；作者得出结论，由于生物胶在神经功能方面的结果相当，且组织学结果更好，因此在修复神经时，尤其是在显微缝合技术困难时，使用生物胶更为可取。
