Center for Intelligent NanoBio Materials (CINBM), Ewha Womans University, Seoul 120-750, Korea.
J Am Chem Soc. 2010 Dec 1;132(47):16735-6. doi: 10.1021/ja105809e. Epub 2010 Sep 16.
A chemically well-defined Bio Core@Inorganic Shell nanohybrid, which consists of rationally designed DNA molecule core with a size of ∼100 nm and spherical inorganic nanoshell with an overall thickness of ∼10 nm reassembled with exfoliated layered metal hydroxide (MH nanosheets), is prepared. The DNA encapsulation and its release, due to the pH-dependent solubility of the MH nanoshell, plays a crucial role in maximizing the stability of base sequence-manipulated and probe-functionalized DNA molecules with designed information. The present DNA Core@MH Shell nanohybrid can provide wide bioinspired applications converged with nanotechnology, such as an advanced gene delivery system and a biomedical diagnostics, tracing/collection/sensing system for DNA-based information.
一种化学定义明确的 Bio Core@Inorganic Shell 纳米杂化体，由大小约为 100nm 的经过合理设计的 DNA 分子核心和整体厚度约为 10nm 的球形无机纳米壳组成，该纳米壳由剥离的层状金属氢氧化物 (MH 纳米片) 重新组装而成。由于 MH 纳米壳的 pH 依赖性溶解度，DNA 的封装和释放在最大限度地提高具有设计信息的碱基序列操纵和探针功能化 DNA 分子的稳定性方面起着至关重要的作用。这种 DNA Core@MH Shell 纳米杂化物可以为与纳米技术融合的广泛仿生应用提供帮助，例如先进的基因传递系统和生物医学诊断、基于 DNA 的信息的跟踪/收集/传感系统。
