Harvard/Farber Cancer Center, Brigham and Women's Hospital, Boston, MA 02115, USA.
Oral Dis. 2010 Oct;16(7):597-600. doi: 10.1111/j.1601-0825.2010.01681.x.
It has been slightly more than a decade since the classic mechanistic paradigm that defined the pathogenesis of mucositis was revised. A five-stage sequence of linked biological events forms the basis for our current understanding of how regimen-related mucosal injury occurs. The first stage is the initiation phase, although the gateway to toxicity has been the least studied. This essay proposes new thoughts on the phase's components, how they might interact, and how they present new opportunities for treatment interventions and mucositis risk prediction.
自经典的机械论范式修正以来，定义黏膜炎发病机制的时间已经过去了十多年。一个由五个相互关联的生物学事件组成的阶段序列构成了我们目前对治疗相关黏膜损伤发生机制的理解基础。第一个阶段是启动阶段，尽管毒性的入口是研究最少的。本文提出了对该阶段组成部分的新思考，它们可能如何相互作用，以及它们如何为治疗干预和黏膜炎风险预测提供新的机会。
