Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Am Acad Dermatol. 2010 Oct;63(4):549-61; quiz 561-2. doi: 10.1016/j.jaad.2010.01.061.
Antiretroviral medications for the treatment of HIV are common drugs with diverse and frequent skin manifestations. Multiple new cutaneous effects have been recognized in the past decade. Dermatologists play an important role in accurately diagnosing and managing the cutaneous toxicities of these medications, thereby ensuring that a patient has as many therapeutic options as possible for life-long viral suppression. Part I of this two-part series on the cutaneous adverse effects of antiretroviral medications will discuss HIV-associated lipodystrophy syndrome, which can be seen as a result of many antiretroviral medications for HIV, and the specific cutaneous effects of the nucleoside reverse transcriptase inhibitors and protease inhibitors.
用于治疗 HIV 的抗逆转录病毒药物是常见药物，具有多种且频繁的皮肤表现。在过去十年中，已经认识到多种新的皮肤效应。皮肤科医生在准确诊断和管理这些药物的皮肤毒性方面发挥着重要作用，从而确保患者拥有尽可能多的治疗选择，以实现长期病毒抑制。这一系列关于抗逆转录病毒药物皮肤不良反应的两部分内容的第一部分将讨论 HIV 相关脂肪营养不良综合征，这是由许多用于 HIV 的抗逆转录病毒药物引起的，以及核苷逆转录酶抑制剂和蛋白酶抑制剂的具体皮肤效应。
