Mitinskaia L A, Demeshko N D, Efimova A A, Litseva O A, Iablokova T B, Levi D T, Pisarenko N N, Kogan E S
Probl Tuberk. 1990(12):3-5.
A comparative effectiveness of the newborn BCG- and BCG-M vaccination was analysed as to the indices of primary infection, morbidity and its structure. The rate of postvaccination complications in 1,645,360 children, aged under 3 years, and living in the areas with different epidemiological situations for tuberculosis was studied too. 2,142,292 and 799486 healthy newborns were BCG- and BCG-M-vaccinated, respectively. The studies were carried out in Moscow, Kiev, Vilnius++ and Tashkent. The obtained results indicate that the number of complications in the form of regional lymphadenitis induced by BCG-M vaccine is 5 times less frequent than those caused by BCG. Under favourable epidemiological conditions, the primary infection and morbidity are alike, while under unfavourable ones the former is higher, particularly in infants in their first year as compared to the BCG-vaccinated. On the basis of the available data BCG-M can be recommended for the vaccination of all the newborns living in the areas with a favourable epidemiological situation for tuberculosis, thus increasing the newborn vaccination coverage and bringing the morbidity down.
对新生儿接种卡介苗（BCG）和卡介苗-麻疹疫苗（BCG-M）的比较效果进行了分析，涉及原发性感染、发病率及其结构指标。还研究了1645360名3岁以下、生活在结核病流行病学情况不同地区的儿童接种疫苗后的并发症发生率。分别对2142292名和799486名健康新生儿接种了卡介苗和卡介苗-麻疹疫苗。研究在莫斯科、基辅、维尔纽斯++和塔什干进行。所得结果表明，卡介苗-麻疹疫苗引起的局部淋巴结炎形式的并发症数量比卡介苗引起的少5倍。在有利的流行病学条件下，原发性感染和发病率相似，而在不利条件下，前者更高，特别是与接种卡介苗的婴儿相比，一岁以内婴儿的情况更为明显。根据现有数据，卡介苗-麻疹疫苗可推荐用于生活在结核病流行病学情况有利地区的所有新生儿接种，从而提高新生儿疫苗接种覆盖率并降低发病率。
