Borba M, Cernea C, Dias F, Faria P, Bacchi C, Brandão L, Costa A
Aristides Maltez Hospital, Salvador da Bahia, Brazil.
ORL J Otorhinolaryngol Relat Spec. 2010;72(6):319-24. doi: 10.1159/000319904. Epub 2010 Sep 16.
To evaluate p63 expression in laryngeal squamous cell carcinoma and its prognostic significance.
p63 expression was examined by immunohistochemistry and scored in 127 patients with laryngeal squamous cell carcinomas.
Sixty-two cases had scored 3, sixty had scored 2, four had scored 1 and one case did not show any expression (48.8, 47.2, 3.1 and 0.8%, respectively). Overall survival was 73.9% at 24 months and 59.5% at 60 months. The disease-free survival was 77.2 and 75.1%, and the disease-specific survival was 79 and 67% at 24 and 60 months, respectively. Uni- and multivariate analysis identified that decreased immunoexpression of protein p63 was a statistically significant factor for the risk of recurrence and death by cancer.
p63 expression was highly prevalent in laryngeal squamous cell carcinomas, and its underexpression was correlated with a worse prognosis.
评估p63在喉鳞状细胞癌中的表达及其预后意义。
采用免疫组织化学法检测127例喉鳞状细胞癌患者的p63表达并进行评分。
62例评分为3分，60例评分为2分，4例评分为1分，1例未显示任何表达（分别为48.8%、47.2%、3.1%和0.8%）。24个月时总生存率为73.9%，60个月时为59.5%。无病生存率在24个月和60个月时分别为77.2%和75.1%，疾病特异性生存率分别为79%和67%。单因素和多因素分析表明，蛋白p63免疫表达降低是癌症复发和死亡风险的一个具有统计学意义的因素。
p63表达在喉鳞状细胞癌中高度普遍，其低表达与较差的预后相关。
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