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小脑脑炎后的小脑性共济失调和膀胱过度活动症

Cerebellar Ataxia and Overactive Bladder after Encephalitis Affecting the Cerebellum.

作者信息

Sugiyama Megumi, Sakakibara Ryuji, Tsunoyama Kuniko, Takahashi Osamu, Kishi Masahiko, Ogawa Emina, Terada Hitoshi, Tomaru Takanobu

机构信息

Clinical Physiology Unit, Toho University, Sakura, Japan.

出版信息

Case Rep Neurol. 2009 Jul 21;1(1):24-28. doi: 10.1159/000226119.

Abstract

The cerebellum is one of the regions that contribute to urinary dysfunction in humans. A 43-year-old woman at age 35 had an acute onset of encephalitis that led to fever, generalized convulsion and coma. Six months after the disease onset, she regained consciousness and developed generalized myoclonus, cerebellar ataxia and overactive bladder, e.g., urinary urgency, daytime urinary frequency, and urinary incontinence. Eight years after the disease onset, she was revealed to have cerebellar atrophy on MRI, cerebellar hypoperfusion on SPECT, and detrusor overactivity on urodynamic study. Selective inflammation in the cerebellum seemed to produce cerebellar ataxia and overactive bladder in our case.

摘要

小脑是导致人类排尿功能障碍的区域之一。一名43岁女性在35岁时急性发作脑炎,出现发热、全身性惊厥和昏迷。发病6个月后,她恢复意识,并出现全身性肌阵挛、小脑共济失调和膀胱过度活动症,如尿急、日间尿频和尿失禁。发病8年后,MRI显示她有小脑萎缩,SPECT显示小脑灌注不足,尿动力学研究显示逼尿肌过度活动。在我们的病例中,小脑的选择性炎症似乎导致了小脑共济失调和膀胱过度活动症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/2940260/5d1f2bb2174a/crn0001-0024-f01.jpg

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