使用拟交感神经药减肥的经验（大多为负面）。
Experience (mostly negative) with the use of sympathomimetic agents for weight loss.
作者信息
Inchiosa Mario A
机构信息
Departments of Pharmacology and Anesthesiology, New York Medical College, Valhalla, NY 10595, USA.
出版信息
J Obes. 2011;2011. doi: 10.1155/2011/764584. Epub 2010 Aug 12.
Abstract
Sympathomimetic agents have a poor history of long-term success in the treatment of obesity. From earlier experiences with amphetamine and its analogs, to more recent drugs with direct effects on adrenergic receptors or indirect effects from release of catecholamines or inhibition of reuptake, cardiovascular toxicity (strokes and cardiac arrhythmias) has been the major concern. These concerns also extended to food supplements containing ephedra alkaloids and may require consideration for current supplements containing the sympathomimetic drug, synephrine.
摘要
拟交感神经药在肥胖治疗方面长期以来疗效不佳。从早期使用苯丙胺及其类似物的经验，到近期对肾上腺素能受体有直接作用或通过释放儿茶酚胺或抑制再摄取产生间接作用的药物，心血管毒性（中风和心律失常）一直是主要问题。这些问题也延伸到含有麻黄生物碱的食品补充剂，对于目前含有拟交感神经药物辛弗林的补充剂可能也需要加以考虑。
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本文引用的文献
1
Concerning ephedra alkaloids for weight loss.
Int J Obes (Lond). 2007 Sep;31(9):1481; author reply 1482-3. doi: 10.1038/sj.ijo.0803574. Epub 2007 Apr 17.
2
Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment.
J Clin Endocrinol Metab. 2007 Apr;92(4):1560-3. doi: 10.1210/jc.2006-2499. Epub 2007 Feb 6.
3
Paradoxical effect of sibutramine on autonomic cardiovascular regulation.
Circulation. 2002 Nov 5;106(19):2459-65. doi: 10.1161/01.cir.0000036370.31856.73.
4
Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat.
Br J Pharmacol. 1997 Aug;121(8):1613-8. doi: 10.1038/sj.bjp.0701311.
5
Pharmacokinetics and cardiovascular effects of ma-huang (Ephedra sinica) in normotensive adults.
J Clin Pharmacol. 1997 Feb;37(2):116-22. doi: 10.1002/j.1552-4604.1997.tb04769.x.
6
Determination of synephrine enantiomers in food and conjugated synephrine in urine by high-performance liquid chromatography with electrochemical detection.
Anal Biochem. 1996 Mar 15;235(2):191-4. doi: 10.1006/abio.1996.0111.
7
The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation.
Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):575-84. doi: 10.1016/0278-5846(88)90003-6.
8
The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride.
Neuropharmacology. 1989 Feb;28(2):129-34. doi: 10.1016/0028-3908(89)90048-8.
9
A comparison of various antidepressant drugs demonstrates rapid desensitisation of alpha 2-adrenoceptors exclusively by sibutramine hydrochloride.
Psychopharmacology (Berl). 1992;107(4):497-502. doi: 10.1007/BF02245262.
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