MHC 家族 Fc 受体 FcRn 的临床意义。
Clinical ramifications of the MHC family Fc receptor FcRn.
机构信息
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
出版信息
J Clin Immunol. 2010 Nov;30(6):790-7. doi: 10.1007/s10875-010-9458-6. Epub 2010 Sep 17.
Abstract
INTRODUCTION
Knowledge that antibodies of the IgG isotype have remarkably extended persistence in circulation and are able to pass through cell barriers has substantial implications. While it is well established that so-called neonatal Fc receptor, FcRn, acts throughout life to confer these unusual properties, its ramifications on clinical medicine and therapeutic uses are not broadly appreciated.
SCOPE
Here we discuss basic principles and gaps in understanding of FcRn, including its management of IgG antibodies and along with albumin, its impact on use and design of antibody-based therapeutics, and its genetics.
摘要
简介
人们已经了解到 IgG 型抗体在血液循环中有显著的延长半衰期，并能够穿透细胞屏障，这具有重要意义。虽然众所周知，所谓的新生儿 Fc 受体（FcRn）在整个生命周期中发挥作用，赋予了这些不寻常的特性，但它对临床医学和治疗用途的影响并没有被广泛认识。
范围
本文讨论了 FcRn 的基本原理和理解上的差距，包括它对 IgG 抗体的管理，以及与白蛋白一起，它对基于抗体治疗药物的使用和设计的影响，以及它的遗传学。
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