Institute of Epidemiology, School of Medicine, University of Belgrade, Belgrade, Serbia.
Int Urol Nephrol. 2011 Jun;43(2):303-8. doi: 10.1007/s11255-010-9828-2. Epub 2010 Sep 17.
The objective is to assess risk factors and microbiological aspects of hospital-acquired urinary tract infection (HAUTI) on six wards of a general regional hospital in Serbia. A case-control study was nested within prospective cohort HAUTIs study conducted from January 1 to December 31, 2007. Three controls were identified for each patient with HAUTI, being chronologically the next three patients surveyed who did not develop HAUTI. The patients and controls were matched by sex and age (±5 years). Assessment of 8,467 patients during the study period revealed HAUTI in 125 (116 symptomatic and 9 asymptomatic). The overall incidence rate of HAUTI was 14.8 cases/1,000 admissions. The mean age (range) of cases and controls was 64.9 (18-85) and 65.2 (17-86), respectively. Multivariate logistic regression analysis showed that duration of catheterization >5 days (OR = 51.91; 95% CI = 23.46-114.82) and the ASA score (OR = 13.42; 95% CI = 2.14-84.30) were independently associated with increased risk of HAUTIs. The most frequently isolated Gram-negative bacteria were Enterobacter, Klebsiella sp., Proteus mirabilis and Escherichia coli. Enterococcus sp. was the most frequent Gram-positive bacteria.
目的在于评估塞尔维亚一家综合区域医院六个病房的医源性尿路感染（HAUTI）的危险因素和微生物学方面。病例对照研究嵌套在 2007 年 1 月 1 日至 12 月 31 日进行的前瞻性队列 HAUTI 研究中。每位 HAUTI 患者均匹配 3 名对照患者，这些对照患者为在 HAUTI 发生前的接下来的 3 名患者，按时间顺序匹配，且性别和年龄（±5 岁）相同。在研究期间对 8467 名患者进行评估，发现 125 名（116 名有症状，9 名无症状）患有 HAUTI。HAUTI 的总发病率为 14.8 例/1000 例住院患者。病例组和对照组的平均年龄（范围）分别为 64.9（18-85）和 65.2（17-86）。多变量逻辑回归分析表明，导管插入时间>5 天（OR = 51.91；95%CI = 23.46-114.82）和 ASA 评分（OR = 13.42；95%CI = 2.14-84.30）与 HAUTI 风险增加独立相关。最常分离的革兰氏阴性菌为肠杆菌、克雷伯菌属、奇异变形杆菌和大肠杆菌。肠球菌属是最常见的革兰氏阳性菌。
