Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
AAPS J. 2010 Dec;12(4):679-82. doi: 10.1208/s12248-010-9228-7. Epub 2010 Sep 18.
The proteome and peptidome are defined as the set of proteins and peptides present in a tissue or other biological sample. In most proteomic studies, only abundant proteins are detected and, although these are important molecules, they are often well-studied structural proteins. A number of approaches have been used to examine less abundant molecules that play roles in signaling or otherwise have regulatory functions, including peptides as well as proteins such as enzymes and receptors. The overarching goals of this special issue involve defining the peptidome, identifying the current state of the field, and discussing methods to characterize the peptides, their receptors, and future needs for such measurements.
蛋白质组和肽组被定义为存在于组织或其他生物样本中的蛋白质和肽的集合。在大多数蛋白质组学研究中，仅检测到丰富的蛋白质，尽管这些是重要的分子，但它们通常是研究充分的结构蛋白。已经使用了许多方法来研究在信号转导中发挥作用或以其他方式具有调节功能的较不丰富的分子，包括肽以及酶和受体等蛋白质。本特刊的总体目标涉及定义肽组，确定该领域的当前状况，并讨论表征肽、其受体以及此类测量未来需求的方法。
