Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.
Head Neck. 2011 Feb;33(2):244-50. doi: 10.1002/hed.21437.
Activation of the hedgehog pathway may contribute to carcinogenesis. This study characterizes the expression pattern in squamous cell carcinoma of the skin and the head and neck.
Tissue microarrays were constructed with samples of squamous cell carcinoma of the skin and the head and neck. All tissue samples were immunohistochemically stained for 7 Hedgehog pathway molecules.
Significant (p < .0001) overexpression of all evaluated molecules could be observed in the tumor samples compared with healthy control tissues. Expression of Gli-2 showed significant upregulation and that of Smoothened and Patched significant downregulation in head and neck compared with skin carcinoma. High expression of Sonic hedgehog correlates significantly (p = .001) with poor overall survival in patients with head and neck cancer.
Hedgehog signaling is differentially regulated in squamous cell carcinomas of the skin and the head and neck. Sonic hedgehog expression may serve as a prognostic factor in patients with head and neck cancer.
hedgehog 通路的激活可能有助于癌症的发生。本研究描绘了皮肤和头颈部鳞状细胞癌中的表达模式。
构建了皮肤和头颈部鳞状细胞癌的组织微阵列。所有组织样本均通过免疫组织化学方法对 7 种 hedgehog 通路分子进行染色。
与健康对照组织相比，肿瘤样本中所有评估的分子均有显著（p<0.0001）过表达。与皮肤癌相比，Gli-2 的表达显著上调，Smoothened 和 Patched 的表达显著下调。 Sonic hedgehog 的高表达与头颈部癌症患者的总生存不良显著相关（p=0.001）。
hedgehog 信号在皮肤和头颈部鳞状细胞癌中存在差异调节。 Sonic hedgehog 的表达可能对头颈部癌症患者的预后有一定的提示作用。
