Putnová Iveta, Putnová Barbora Moldovan, Hurník Pavel, Štembírek Jan, Buchtová Marcela, Kolísková Petra
Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.
Department of Anatomy, Histology and Embryology, University of Veterinary Sciences Brno, Brno, Czechia.
Front Oncol. 2024 Aug 21;14:1413255. doi: 10.3389/fonc.2024.1413255. eCollection 2024.
Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area.
头颈部鳞状细胞癌（SCC）起源于上呼吸消化道的黏膜内衬，包括唇部、舌部、鼻咽部、口咽部、喉部和下咽。在本综述中，我们总结了目前已知的原发性纤毛在该疾病发病机制中的潜在作用。由于原发性纤毛是信号转导的关键细胞结构且与细胞增殖相关，因此了解其在致癌作用中的作用对于设计新的治疗方法至关重要。在此，我们介绍头颈部鳞状细胞癌（HNSCC）中与纤毛相关的信号传导及其与HNSCC肿瘤发生的可能关联。从这一角度出发，讨论了血小板衍生生长因子（PDGF）、表皮生长因子（EGF）、Wnt和Hh信号传导，因为在HNSCC中发现所有这些信号通路均失调。此外，我们综述了影响原发性纤毛信号传导的小分子对头颈部鳞状细胞癌的临床治疗潜力。
