头颈部鳞状细胞癌中 p21 和 Ki-67 的共过表达与预后显著不良相关。
Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis.
机构信息
Department of Otolaryngology, Head and Neck Surgery, University Hospital, Basel, Switzerland.
出版信息
Head Neck. 2011 Feb;33(2):267-73. doi: 10.1002/hed.21440.
BACKGROUND
Head and neck squamous cell carcinomas (HNSCC) are treated by surgery or radiotherapy. Tumor cell death-related markers, such as p21 and Ki-67, may predict response to therapy and improve treatment choice. We evaluated and compared the effect of their coexpression between patients treated by surgery or radiotherapy.
METHODS
Immunohistochemistry for p21 and Ki-67 expression in 144 pharyngeal and laryngeal HNSCC samples was analyzed and correlated with follow-up parameters.
RESULTS
p21 expression correlated significantly with positive cN classification (p < .001), locoregional relapse (p = .031), and poor overall survival (p = .016), and Ki-67 positivity with poor survival only (p = .025). Coexpressing tumor phenotypes showed the worst survival (p = .009), observed primarily in patients treated by radiotherapy (p = .077).
CONCLUSIONS
Coexpression of p21/Ki-67 is a strong negative prognostic factor in HNSCC and could be of particular relevance in tumors treated by primary radiotherapy.
背景
头颈部鳞状细胞癌（HNSCC）的治疗方法有手术或放疗。肿瘤细胞死亡相关标志物，如 p21 和 Ki-67，可能预测对治疗的反应，并改善治疗选择。我们评估并比较了手术或放疗患者之间它们共同表达的效果。
方法
对 144 例咽和喉 HNSCC 样本的 p21 和 Ki-67 表达进行免疫组织化学分析，并与随访参数相关联。
结果
p21 表达与阳性 cN 分类（p<0.001）、局部区域复发（p=0.031）和总体生存不良（p=0.016）显著相关，Ki-67 阳性与生存不良仅相关（p=0.025）。共表达的肿瘤表型显示出最差的生存（p=0.009），主要见于接受放射治疗的患者（p=0.077）。
结论
p21/Ki-67 的共表达是 HNSCC 的一个强烈的预后不良因素，在接受原发放疗的肿瘤中可能具有特别重要的意义。
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