Department of Otolaryngology, Head and Neck Surgery, University Hospital, Basel, Switzerland.
Head Neck. 2011 Feb;33(2):267-73. doi: 10.1002/hed.21440.
Head and neck squamous cell carcinomas (HNSCC) are treated by surgery or radiotherapy. Tumor cell death-related markers, such as p21 and Ki-67, may predict response to therapy and improve treatment choice. We evaluated and compared the effect of their coexpression between patients treated by surgery or radiotherapy.
Immunohistochemistry for p21 and Ki-67 expression in 144 pharyngeal and laryngeal HNSCC samples was analyzed and correlated with follow-up parameters.
p21 expression correlated significantly with positive cN classification (p < .001), locoregional relapse (p = .031), and poor overall survival (p = .016), and Ki-67 positivity with poor survival only (p = .025). Coexpressing tumor phenotypes showed the worst survival (p = .009), observed primarily in patients treated by radiotherapy (p = .077).
Coexpression of p21/Ki-67 is a strong negative prognostic factor in HNSCC and could be of particular relevance in tumors treated by primary radiotherapy.
头颈部鳞状细胞癌（HNSCC）的治疗方法有手术或放疗。肿瘤细胞死亡相关标志物，如 p21 和 Ki-67，可能预测对治疗的反应，并改善治疗选择。我们评估并比较了手术或放疗患者之间它们共同表达的效果。
对 144 例咽和喉 HNSCC 样本的 p21 和 Ki-67 表达进行免疫组织化学分析，并与随访参数相关联。
p21 表达与阳性 cN 分类（p<0.001）、局部区域复发（p=0.031）和总体生存不良（p=0.016）显著相关，Ki-67 阳性与生存不良仅相关（p=0.025）。共表达的肿瘤表型显示出最差的生存（p=0.009），主要见于接受放射治疗的患者（p=0.077）。
p21/Ki-67 的共表达是 HNSCC 的一个强烈的预后不良因素，在接受原发放疗的肿瘤中可能具有特别重要的意义。
