Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland.
Inflamm Bowel Dis. 2010 Dec;16(12):2131-6. doi: 10.1002/ibd.21300.
Few data exist of prospective parallel scoring of the validated endoscopic scores in Crohn's disease (CD), Crohn's Disease Index of Severity (CDEIS), and Simple Endoscopic Score for Crohn's Disease (SES-CD).
Both the CDEIS and the SES-D were scored immediately after each endoscopy of 86 CD patients referred for ileocolonoscopy in a cross-sectional study. Furthermore, after CD therapy, 32 CD patients underwent a follow-up endoscopy with scoring of the CDEIS and SES-CD. Endoscopic scorings were graded as inactive, mild, moderate, or severe. Clinical activity was assessed with the Crohn's Disease Activity Index (CDAI) and serum C-reactive protein (CRP) was measured.
The SES-CD correlated with the CDEIS significantly (Spearman's r = 0.938, P < 0.0001). Weaker correlations were detected between the SES-CD and the CDAI (r = 0.473) or CRP (r = 0.525, both P < 0.0001). Grading of SES-CD from inactive to severe correlated significantly with grading of the CDEIS (r = 0.859, P < 0.0001). Changes between baseline and follow-up endoscopy scores correlated significantly (r = 0.828 between delta-CDEIS and delta-SES-CD, P < 0.001), but failed to correlate with delta-CDAI or delta-CRP (all P > 0.05).
Both validated endoscopic scores, the CDEIS and SES-CD, and their changes during CD therapy demonstrated a close correlation. For scoring of endoscopic activity in clinical routine, the SES-CD could replace the CDEIS.
目前很少有前瞻性平行评分克罗恩病（CD）验证内镜评分、克罗恩病严重程度指数（CDEIS）和简单 CD 内镜评分（SES-CD）的资料。
在一项横断面研究中，对 86 例因回肠结肠镜检查而转介的 CD 患者进行内镜检查后，立即对 CDEIS 和 SES-CD 进行评分。此外，在 CD 治疗后，32 例 CD 患者进行了随访内镜检查，对 CDEIS 和 SES-CD 进行了评分。内镜评分分为不活动、轻度、中度或重度。临床活动通过克罗恩病活动指数（CDAI）进行评估，并测量血清 C 反应蛋白（CRP）。
SES-CD 与 CDEIS 显著相关（Spearman's r = 0.938，P < 0.0001）。SES-CD 与 CDAI（r = 0.473）或 CRP（r = 0.525，均 P < 0.0001）之间的相关性较弱。SES-CD 从不活动到严重的分级与 CDEIS 的分级显著相关（r = 0.859，P < 0.0001）。基线和随访内镜评分之间的变化显著相关（delta-CDEIS 和 delta-SES-CD 之间的 r = 0.828，P < 0.001），但与 delta-CDAI 或 delta-CRP 无关（均 P > 0.05）。
两种验证性内镜评分 CDEIS 和 SES-CD 及其在 CD 治疗过程中的变化均表现出密切相关性。在临床常规中进行内镜活动评分时，SES-CD 可替代 CDEIS。
