Zhao Xi, Yan Wei, Wang Li, Feng Qinyu, Pang Yingzhi, Wang Yanping, Tao Meihui, Zhang Jingyue, Fu Yu
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Int J Gen Med. 2025 Sep 4;18:5115-5125. doi: 10.2147/IJGM.S529428. eCollection 2025.
To explore the correlation of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) with inflammatory bowel disease activity and their value in predicting disease activity.
Clinical data of 490 adult IBD patients diagnosed in two IBD centers were collected, and 200 healthy people were served as controls. To evaluate the correlation of IDL and HDL with clinical and endoscopic activity of inflammatory bowel disease (IBD), and to explore the predictive value of them for disease activity.
In CD, there were differences in HDL, CRP and ESR levels (p<0.001) among different disease activity groups. HDL levels were negatively correlated with HBI and CDEIS. In UC, there were differences in LDL, HDL, CRP and ESR levels among groups with different disease activities (p<0.001). Both LDL and HDL levels were negatively correlated with Mayo clinical score and UCEIS (p<0.001). The sensitivity of LDL for predicting moderate-severe UC was slightly higher than CRP (65.65% vs 60.31%). The specificity of HDL in predicting moderate-severe CD (65.85% vs 52.44%) and UC (87.34% vs 79.75%) was higher than CRP.
In patients with IBD, serum levels of both LDL and HDL were significantly lower compared to healthy controls. These levels correlated with disease activity. Furthermore, LDL and HDL levels demonstrated potential utility in distinguishing patients with moderate-severe IBD and show promise as monitoring biomarkers for IBD.
探讨低密度脂蛋白（LDL）和高密度脂蛋白（HDL）与炎症性肠病活动度的相关性及其预测疾病活动度的价值。
收集在两个炎症性肠病中心确诊的490例成年炎症性肠病患者的临床资料，并选取200名健康人作为对照。评估IDL和HDL与炎症性肠病（IBD）临床及内镜活动度的相关性，并探讨其对疾病活动度的预测价值。
在克罗恩病（CD）中，不同疾病活动度组间HDL、CRP和ESR水平存在差异（p<0.001）。HDL水平与HBI和CDEIS呈负相关。在溃疡性结肠炎（UC）中，不同疾病活动度组间LDL、HDL、CRP和ESR水平存在差异（p<0.001）。LDL和HDL水平均与梅奥临床评分和UCEIS呈负相关（p<0.001）。LDL预测中重度UC的敏感性略高于CRP（65.65%对60.31%）。HDL预测中重度CD（65.85%对52.44%）和UC（87.34%对79.75%）的特异性高于CRP。
在炎症性肠病患者中，与健康对照相比，血清LDL和HDL水平均显著降低。这些水平与疾病活动度相关。此外，LDL和HDL水平在区分中重度炎症性肠病患者方面显示出潜在效用，并有望作为炎症性肠病的监测生物标志物。
