Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr B. R. Ambedkar Veedhi, Bangalore-560 001, India.
J Pept Sci. 2010 Nov;16(11):644-51. doi: 10.1002/psc.1276.
An important class of organoselenium compounds-α-isoselenocyanato esters 4 has been prepared by a reaction of α-isocyano esters with elemental selenium powder. The reaction issimple, rapid and all the isoselenocyanates have been isolated as stable ones after chromatographic purification. These hitherto unreported classes of molecules would be useful building blocks for the preparation of variety of selenium containing peptidomimetics. In this study, the utility of the title molecules in the preparation of selenoureidopeptidomimetics 6, unsymmetrical selenoureas 8 and selenohydantoins 10 is demonstrated.
一类重要的有机硒化合物——α-异硒氰酸酯 4 可以通过α-异氰酸酯与元素硒粉的反应来制备。该反应简单、快速，所有的异硒氰酸酯在经过色谱纯化后都被分离出来，作为稳定的产物。这些迄今未报道的分子类别将是制备各种含硒肽模拟物的有用构建块。在这项研究中，标题分子在制备硒脲肽模拟物 6、不对称硒脲 8 和硒代乙内酰脲 10 中的应用得到了证明。
