Nong Xiao-lin, Xia Yong, Yang Yi-ping, Qing Hai-yun, Li Jia-quan, Li Yan-ning, Cao Yang, Li Hao, Chen Qi
Dept. of Oral and Maxillofacial Surgery, Stomatological College, Guangxi Medical University, Nanning 530021, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2010 Aug;28(4):420-4, 429.
To determine the effect of tyrosine kinase A (TrkA) and vascular endothelial growth factor receptor 2 (VEGFR2) in the invasion and metastasis of salivary adenoid cystic carcinoma (SACC).
The expression of TrkA and VEGFR2 were detected by immunohistochemical staining in 47 cases of SACC of salivary glands. Clinical data were reviewed by multivariate prognostic analysis.
The positive rate of TrkA and VEGFR2 in SACC was 87.23% (41/47) and 85.11% (40/47) respectively. Express of TrkA and VEGFR2 in perineural invasion and recurrence group were higher than non-perineural invasion and non-recurrence group. Significant difference was found in microvessel density (MVD) and VEGFR2 expression within different groups (P < 0.05). MVD in perineural invasion group (25.14 +/- 2.83) was significantly higher than that in none perineural invasion group (18.81 +/- 1.33) (P < 0.05). MVD in recurrence or metastasis group (26.58 +/- 2.38) was significantly higher than that (19.06 +/- 1.39) in none recurrence nor metastasis group (P < 0.05).
Positive correlation between expression of TrkA, VEGFR2 and nerve invasion and vessel metastasis of SACC indicate that TrkA and VEGFR2 play important roles in the invasion and metastasis of SACC. It is possible that TrkA and VEGFR2 could be an aid for evaluating the prognosis of SACC patients.
确定酪氨酸激酶A（TrkA）和血管内皮生长因子受体2（VEGFR2）在涎腺腺样囊性癌（SACC）侵袭和转移中的作用。
采用免疫组织化学染色法检测47例涎腺SACC中TrkA和VEGFR2的表达。通过多因素预后分析回顾临床资料。
SACC中TrkA和VEGFR2的阳性率分别为87.23%（41/47）和85.11%（40/47）。TrkA和VEGFR2在神经侵犯和复发组中的表达高于非神经侵犯和非复发组。不同组间微血管密度（MVD）和VEGFR2表达存在显著差异（P<0.05）。神经侵犯组的MVD（25.14±2.83）显著高于无神经侵犯组（18.81±1.33）（P<0.05）。复发或转移组的MVD（26.58±2.38）显著高于无复发和无转移组（19.06±1.39）（P<0.05）。
TrkA、VEGFR2表达与SACC神经侵犯和血管转移呈正相关，表明TrkA和VEGFR2在SACC侵袭和转移中起重要作用。TrkA和VEGFR2有可能有助于评估SACC患者的预后。
