Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, PR China.
Oral Oncol. 2010 Oct;46(10):755-60. doi: 10.1016/j.oraloncology.2010.08.008. Epub 2010 Sep 17.
Extracellular matrix metalloproteinase inducer (EMMPRIN) plays a critical role in the progression of malignancies by stimulating expression of metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) in stromal cells. However, the expression of EMMPRIN in adenoid cystic carcinoma (ACC) of salivary glands, and its correlation with patients' prognosis have never been investigated thus far. In the present study, the expression of EMMPRIN was examined in 72 ACCs and 20 normal salivary gland tissues by immunohistochemistry. The expression of MMP-2, MMP-9, VEGF, Ki-67 index, and microvessel density (MVD) labeled by CD31 were also assessed by immunohistochemistry in ACCs. The positivity of EMMPRIN in ACCs was 62.5%, which was significantly higher than that in normal salivary gland tissues (P<0.01). EMMPRIN expression was positively correlated with tumor size, histotypes, clinical stage, perineural invasion, vascular invasion, metastasis, expression of MMP-2, MMP-9, VEGF, Ki-67 index, and MVD (P<0.05), but not with gender, age, tumor site or recurrence (P>0.05). Multivariate analysis showed that EMMPRIN expression, Ki-67 index, and solid histotype had an independent prognostic effect on overall survival (P<0.05). According to our findings, EMMPRIN might actively be involved in the growth, angiogenesis, invasion and metastasis of ACCs. Measurement of EMMPRIN may be helpful in predicting patients' prognosis and understanding the malignant behaviors of ACCs.
细胞外基质金属蛋白酶诱导因子（EMMPRIN）通过刺激基质细胞中金属蛋白酶（MMPs）和血管内皮生长因子（VEGF）的表达，在恶性肿瘤的进展中发挥关键作用。然而，迄今为止，腺泡状横纹肌肉瘤（ACC）中 EMMPRIN 的表达及其与患者预后的关系尚未得到研究。在本研究中，通过免疫组织化学法检测了 72 例 ACC 和 20 例正常涎腺组织中 EMMPRIN 的表达。还通过免疫组织化学法评估了 MMP-2、MMP-9、VEGF、Ki-67 指数和 CD31 标记的微血管密度（MVD）在 ACC 中的表达。ACC 中 EMMPRIN 的阳性率为 62.5%，明显高于正常涎腺组织（P<0.01）。EMMPRIN 的表达与肿瘤大小、组织类型、临床分期、神经周围侵犯、血管侵犯、转移、MMP-2、MMP-9、VEGF、Ki-67 指数和 MVD 的表达呈正相关（P<0.05），但与性别、年龄、肿瘤部位或复发无关（P>0.05）。多因素分析显示，EMMPRIN 表达、Ki-67 指数和实体组织学类型对总生存率有独立的预后影响（P<0.05）。根据我们的发现，EMMPRIN 可能积极参与了 ACC 的生长、血管生成、侵袭和转移。测量 EMMPRIN 可能有助于预测患者的预后并了解 ACC 的恶性行为。
