手性有机催化醛与三氟亚乙基丙二酸二乙酯的迈克尔加成反应。
Enantioselective organocatalytic Michael addition of aldehydes to trifluoroethylidene malonates.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PRC.
出版信息
Org Lett. 2010 Oct 15;12(20):4655-7. doi: 10.1021/ol101894h.
PMID:20849077
Abstract
An efficient, highly enantioselective, organocatalytic Michael addition reaction of aldehydes with trifluoroethylidene malonates is described. The asymmetric reaction provided highly optically pure β-trifluoromethyl aldehydes which can be conveniently transformed into 4,4,4-trifluoromethyl butyric acid and trifluoromethyl substituted δ-lactones without loss in enantioselectivity.
摘要
描述了一种高效、高对映选择性的醛与三氟亚乙基丙二酸酯的有机催化迈克尔加成反应。不对称反应提供了高光学纯度的β-三氟甲基醛，这些醛可以方便地转化为 4,4,4-三氟丁酸和三氟取代的δ-内酯，而对映选择性没有损失。
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