Hyperthermia unit, Department of Radiation Oncology, Daniel den Hoed Cancer Centre, Erasmus MC, Rotterdam, The Netherlands.
Int J Hyperthermia. 2010;26(7):638-48. doi: 10.3109/02656736.2010.495104.
For superficial hyperthermia a custom-built multi-applicator multi-amplifier superficial hyperthermia system operating at 433 MHz is utilised. Up to 6 Lucite Cone applicators can be used simultaneously to treat an area of 600 cm2. Temperatures are measured continuously with fibre optic multi-sensor probes. For patients with non-standard clinical problems, hyperthermia treatment planning is used to support decision making with regard to treatment strategy. In 74% of our patients with recurrent breast cancer treated with a reirradiation scheme of 8 fractions of 4 Gy in 4 weeks, combined with 4 or 8 hyperthermia treatments, a complete response is achieved, approximately twice as high as the CR rate following the same reirradation alone. The CR rate in tumours smaller than 30 mm is 80-90%, for larger tumours it is 65%. Hyperthermia appears beneficial for patients with microscopic residual tumour as well. To achieve high CR rates it is important to heat the whole radiotherapy field, and to use an adequate heating technique.
对于表浅加热，使用定制的多应用器多放大器表浅加热系统，工作频率为 433MHz。最多可以同时使用 6 个 Lucite 锥型辐射器，以治疗 600cm2 的面积。采用光纤多传感器探头连续测量温度。对于具有非标准临床问题的患者，热疗治疗计划用于支持治疗策略的决策。在我们 74%接受 8 个 4Gy 分次 4 周再放疗方案联合 4 或 8 次热疗治疗的复发性乳腺癌患者中，完全缓解率达到 65%，是单纯接受相同再放疗的患者的两倍。肿瘤小于 30mm 的患者的完全缓解率为 80-90%，肿瘤大于 30mm 的患者为 65%。热疗对有镜下残留肿瘤的患者也有好处。为了达到高的完全缓解率，重要的是要加热整个放疗野，并使用适当的加热技术。
